Reviewed, UniProtKB/Swiss-Prot A7HFW2 (NTPA_ANADF)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

Anae109_3424

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Nucleoside-triphosphatase		PRO_1000068408

Sequences

	Sequence		Length	Mass (Da)
	A7HFW2-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 81C86C49BA0C9F23	FASTA	230	24,034
	10 20 30 40 50 60 MDLLFASTNP GKLKELRRLV AGLPIRVVSP DELPRALPEV EEDGATFQAN AEKKASTYAR 70 80 90 100 110 120 LAGMAALADD SGLAVDALGG APGVRSARWS DEEPGPAPAS PVCDLAEAAA AELGPVAGRG 130 140 150 160 170 180 ARDERNNDKL LRSLAGLPDE RRGAQYEAVL AVARADGSLV ASVAGVCRGR IGHARRGTGG 190 200 210 220 230 FGYDPLFVPD GQGGRTMAEL SAEEKDAISH RGDAFRRIRS LLERLAREGA

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS27608.1.
RefSeq	YP_001380592.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5375175.
GenomeReviews	Gene locus Anae109_3424 in contig CP000769_GR.
KEGG	afw:Anae109_3424.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_ANADF

Accession

Primary (citable) accession number: A7HFW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	July 22, 2008
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)