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A7HDC9

- GCSPA_ANADF

UniProt

A7HDC9 - GCSPA_ANADF

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Anae109_2524
Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciASP404589:GHMT-2548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Anae109_2524
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000006382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045636Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi404589.Anae109_2524.

Structurei

3D structure databases

ProteinModelPortaliA7HDC9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HDC9-1 [UniParc]FASTAAdd to Basket

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MRYHPHTPED VRAMLDVIGA ESLDDLFRSI PERLRLARPL DLPPAADEIT    50
LFAELRALAA RDDTAHPPFV GAGCYPHHVP PAVDQLLLRG EFFTAYTPYQ 100
PEVSQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATAMAE AALMATRVTG 150
RSKIVVSAAV HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLRALEAAVD 200
GGTAAVIVGY PSFLGVVDAL PQAAAIAKKA GALTVAVTAE AVALGLLQAP 250
GALGADVAVG TFQSFGNPMS FGGPAPGFFA IREQFVRQMP GRVCGATVDK 300
HGRRGFVLTL STREQHIRRE KATSNICTNS GLAALAATIH LALLGKQGLA 350
ELARLNFARA RMLKDALGRA GIAPLFSAPP FNELAFDVGD AEAVVARLAK 400
RGIAAGAPLA RWYPELPRAK GALLSVATEL HTPELIELFA QSVKG 445
Length:445
Mass (Da):47,154
Last modified:September 11, 2007 - v1
Checksum:i77FB838772F1FBE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS26725.1.
RefSeqiWP_012097318.1. NC_009675.1.
YP_001379709.1. NC_009675.1.

Genome annotation databases

EnsemblBacteriaiABS26725; ABS26725; Anae109_2524.
GeneIDi5377829.
KEGGiafw:Anae109_2524.
PATRICi20930357. VBIAnaSp113478_2643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS26725.1 .
RefSeqi WP_012097318.1. NC_009675.1.
YP_001379709.1. NC_009675.1.

3D structure databases

ProteinModelPortali A7HDC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404589.Anae109_2524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS26725 ; ABS26725 ; Anae109_2524 .
GeneIDi 5377829.
KEGGi afw:Anae109_2524.
PATRICi 20930357. VBIAnaSp113478_2643.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci ASP404589:GHMT-2548-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fw109-5.

Entry informationi

Entry nameiGCSPA_ANADF
AccessioniPrimary (citable) accession number: A7HDC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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