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A7HDC9

- GCSPA_ANADF

UniProt

A7HDC9 - GCSPA_ANADF

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciASP404589:GHMT-2548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Anae109_2524
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000006382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045636Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi404589.Anae109_2524.

Structurei

3D structure databases

ProteinModelPortaliA7HDC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HDC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYHPHTPED VRAMLDVIGA ESLDDLFRSI PERLRLARPL DLPPAADEIT
60 70 80 90 100
LFAELRALAA RDDTAHPPFV GAGCYPHHVP PAVDQLLLRG EFFTAYTPYQ
110 120 130 140 150
PEVSQGTLQA LFEWQTFVCL LTGMDVSNAS MYDGATAMAE AALMATRVTG
160 170 180 190 200
RSKIVVSAAV HPEYRKVLAT YLRSTGDEIV TVPFGADGRT DLRALEAAVD
210 220 230 240 250
GGTAAVIVGY PSFLGVVDAL PQAAAIAKKA GALTVAVTAE AVALGLLQAP
260 270 280 290 300
GALGADVAVG TFQSFGNPMS FGGPAPGFFA IREQFVRQMP GRVCGATVDK
310 320 330 340 350
HGRRGFVLTL STREQHIRRE KATSNICTNS GLAALAATIH LALLGKQGLA
360 370 380 390 400
ELARLNFARA RMLKDALGRA GIAPLFSAPP FNELAFDVGD AEAVVARLAK
410 420 430 440
RGIAAGAPLA RWYPELPRAK GALLSVATEL HTPELIELFA QSVKG
Length:445
Mass (Da):47,154
Last modified:September 11, 2007 - v1
Checksum:i77FB838772F1FBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA. Translation: ABS26725.1.
RefSeqiWP_012097318.1. NC_009675.1.
YP_001379709.1. NC_009675.1.

Genome annotation databases

EnsemblBacteriaiABS26725; ABS26725; Anae109_2524.
GeneIDi5377829.
KEGGiafw:Anae109_2524.
PATRICi20930357. VBIAnaSp113478_2643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA. Translation: ABS26725.1 .
RefSeqi WP_012097318.1. NC_009675.1.
YP_001379709.1. NC_009675.1.

3D structure databases

ProteinModelPortali A7HDC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404589.Anae109_2524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS26725 ; ABS26725 ; Anae109_2524 .
GeneIDi 5377829.
KEGGi afw:Anae109_2524.
PATRICi 20930357. VBIAnaSp113478_2643.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci ASP404589:GHMT-2548-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fw109-5.

Entry informationi

Entry nameiGCSPA_ANADF
AccessioniPrimary (citable) accession number: A7HDC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3