A7HDB7 (PUR5_ANADF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Anae109_2512

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_B
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_B.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_B		PRO_1000046419

Sequences

	Sequence		Length	Mass (Da)
	A7HDB7 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 47F4BB0FA26532B6	FASTA	344	36,202
	10 20 30 40 50 60 MSLTYRDAGV DIDEGDRLVE LIKPHARPTL RPEVLAGIGG FGGLFALDVK KYREPVLVSG 70 80 90 100 110 120 TDGVGTKLKV AFAANRHDTI GIDLVAMCVN DVAVVGAEPL FFLDYFGTGK LSAEQGAEVV 130 140 150 160 170 180 KGIAEGCRQA GCALIGGETA ELPGFYAPGE YDLAGFAVGC VERSRIVDGK GVAPGDVVVG 190 200 210 220 230 240 VASTGLHSNG YSLARKALMD RHPLDRRFDG LGGRTLGEAL LEPTRIYAKD VLALLDAVPV 250 260 270 280 290 300 KAFSHITGGG LPGNVPRTLP DGTRAVLEEK RWPRPAIFDL VEREGGVPRD EMYRTFNMGL 310 320 330 340 GLVAVVAPGD EAAAHAALRA RGLDAWTVGQ IEVGTGEATC EVVR

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fw109-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000769 Genomic DNA. Translation: ABS26713.1.
RefSeq	YP_001379697.1. NC_009675.1.
3D structure databases
ProteinModelPortal	A7HDB7.
SMR	A7HDB7. Positions 1-339.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HDB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5377594.
GenomeReviews	Gene locus Anae109_2512 in contig CP000769_GR.
KEGG	afw:Anae109_2512.
NMPDR	fig|404589.4.peg.2173.
PATRIC	20930333. VBIAnaSp113478_2631.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ANADF

Accession

Primary (citable) accession number: A7HDB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program