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A7HCP4 (SYR_ANADF) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Anae109_2288
OrganismAnaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]
Taxonomic identifier404589 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000017984

Regions

Motif131 – 14111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A7HCP4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 0B23EA150215BCBC

FASTA60566,586
        10         20         30         40         50         60 
MVKDRVIELF RQALAKGAAE GRWPALEASF SVEAPRDPKH GDFAVNAAMV LAKAAGKPPR 

        70         80         90        100        110        120 
DLAQAIAAEV RAVDAQHEIA GLEVAGPGFI NVRLAPDVWL RALGRVVAEG TAYGRTEVGR 

       130        140        150        160        170        180 
GKKVIVEYVS ANPTGPMHVG HGRNAVVGDG VQSLLRWAGF EVTREYYVND YGAQVQTLAR 

       190        200        210        220        230        240 
SVHLRYQELF GRQVTMPPKS YPGEYVKDVA AALKAEHGDR WLDAPEAEWL ALFRDRAVEH 

       250        260        270        280        290        300 
VLGLIREDLR AVNIEFDRWY SEKALYESGT VDRFLRFLAE KDLVYVGKLP PPKSKKGQPA 

       310        320        330        340        350        360 
PAQAASNSAH DLGEEGIAAS DDLTLFRSSQ YGDEVDRPVK KADGTTTYFC ADIAYHWDKR 

       370        380        390        400        410        420 
QRADALVDVL GADHGGYVPR LEAALEALGA SRKDLHVVLI QMVNLTRGGE AVKMSKRAGT 

       430        440        450        460        470        480 
VVSLREVVDE VGRDATRFIF LTRRSDAQLD FDIELAKRQT LDNPVFYVQY GHARLAQIFA 

       490        500        510        520        530        540 
KAREAGAPVP EFDLEAARTL TSAEEQDLIR RIVAFPDMLA AAALAYEPHR VAFYLQETIA 

       550        560        570        580        590        600 
AFHSYYTQGK RTGERVISAD ARKTAGRLFL CRALKQVLAN GLGLLGVAAP ERMESPETRD 


LADDV 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. Fw109-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Lykidis A., Fields M., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fw109-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000769 Genomic DNA. Translation: ABS26490.1.
RefSeqYP_001379474.1. NC_009675.1.

3D structure databases

ProteinModelPortalA7HCP4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING404589.Anae109_2288.

Proteomic databases

PRIDEA7HCP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS26490; ABS26490; Anae109_2288.
GeneID5375615.
KEGGafw:Anae109_2288.
PATRIC20929863. VBIAnaSp113478_2397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAYNARENG.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycASP404589:GHMT-2311-MONOMER.

Family and domain databases

Gene3D3.30.1360.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_ANADF
AccessionPrimary (citable) accession number: A7HCP4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries