Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (Anae109_4383)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Binding sitei205ATPUniRule annotation1
Binding sitei296ATP; via carbonyl oxygenUniRule annotation1
Binding sitei327ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi353 – 356ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP404589:G1G9J-2352-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Anae109_2281
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000579581 – 396Phosphoglycerate kinaseAdd BLAST396

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi404589.Anae109_2281

Structurei

3D structure databases

ProteinModelPortaliA7HCN7
SMRiA7HCN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni60 – 63Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiMFAGAIC
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A7HCN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKTIDALD LAGKRVFIRV DFNVPLDEQR RVTDDARIRA ALPTIKHAIQ
60 70 80 90 100
ARAKVILGSH LGRPKGKPDD REKFSLEPAA QRLSELLKQD VILADDCIGD
110 120 130 140 150
GVKKLVRDLK EGQVLLLENL RFHPQEEKND EGFARELATL CDVWVNDAFG
160 170 180 190 200
TAHRAHASTA GMAAFVKEKA AGFLIQKEVE YLGKALGSPE RPFVALIGGA
210 220 230 240 250
KVSDKIKVLE NLIAKADAIC IGGAMAYTFL KAQGVAVGKS LVEEDKLELA
260 270 280 290 300
RQILERAQAR KVDLLLPVDH VCGAEPKDTA ERVVVNDRAI PDGLMGLDIG
310 320 330 340 350
PKTLDRYRQR IVDAKTVFWN GPMGLFEQKP WAEGTFGVAQ AMAQSPAVTV
360 370 380 390
VGGGDSAAAV EEAGLVSKMK HVSTGGGASL EFIEGRVLPG IQVLEG
Length:396
Mass (Da):42,732
Last modified:September 11, 2007 - v1
Checksum:iDADF00E2824FD894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS26483.1
RefSeqiWP_012097068.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS26483; ABS26483; Anae109_2281
KEGGiafw:Anae109_2281

Similar proteinsi

Entry informationi

Entry nameiPGK_ANADF
AccessioniPrimary (citable) accession number: A7HCN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health