Reviewed, UniProtKB/Swiss-Prot A7HCA3 (AHPD_ANADF)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	Anae109_2147

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359469
Sites
	Active site	132	1	Proton donor By similarity
	Active site	135	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	132 ↔ 135		Alternate By similarity
	Disulfide bond	135		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7HCA3-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 7764DC8C4ABBE19F	FASTA	185	19,133
	10 20 30 40 50 60 MSPVDRLREA LPDAARDVRL NLQAVLQGGA LTEGQRWGVA VASAAAARQP ALLSAVLAEA 70 80 90 100 110 120 RSRGLDSAAE DGLAAAALMA MNNVYYRFRH MVGKPGYTEM PARLRMGRLA QPATSRADLE 130 140 150 160 170 180 LFSLAASAIN GCEACVRTHE DVVVKGGIGE EAVHDAVRIA AVIHAAAVAL EAGEVAGGHE AVSAA

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS26349.1.
RefSeq	YP_001379333.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7HCA3.
Genome annotation databases
GeneID	5374379.
GenomeReviews	Gene locus Anae109_2147 in contig CP000769_GR.
KEGG	afw:Anae109_2147.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAMNNVY.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_ANADF

Accession

Primary (citable) accession number: A7HCA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)