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A7HA60

- PUR9_ANADF

UniProt

A7HA60 - PUR9_ANADF

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciASP404589:GHMT-1408-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Anae109_1399
    OrganismiAnaeromyxobacter sp. (strain Fw109-5)
    Taxonomic identifieri404589 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000006382: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Bifunctional purine biosynthesis protein PurHPRO_1000018835Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi404589.Anae109_1399.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HA60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiIRASSKN.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HA60-1 [UniParc]FASTAAdd to Basket

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    MVRRALVSVS DKTGLVPFAK RLAALGVEIL STGGTQRALA DAGVPVVSVG    50
    DYTQAPEILA GRVKTLHPRV HGGILYRRGL ASDEADVKAR DIPPIDLVVV 100
    NLYPFREAVA AGKPFWDCVE EIDIGGPTMV RSAAKNAAHV GVVVDPADYE 150
    RVAAELEASR ALSDQTRFEL MKKAFAHTAA YDAAISEFLT ARESTDAQAK 200
    RFPATLAAVY SKAGDLRYGE NPHQAGAFYR AGREPDEPTV AFAKVLQGKE 250
    LSYNNLLDLE AALAAVKEHD EVACVVIKHN TPCGVSLGKT PAEAFARARA 300
    CDPVSAFGGI VALNRPVDAA AAKELTDLFL ECVIAPGYDE AARAALGAKK 350
    NLRLLEAPRL AEPRTSWTRR PEELRELRSI PGGLLVMDRD LGAIRRDDCK 400
    VMTKRAPTDA EWEDLLFAWK VVKHVKSNAI VFAKEKRTVG IGGGQTSRVE 450
    SVKTAVMKAQ LELVGSTVGS DAFFPFKDGV EEIIKAGATA IIQPGGSVRD 500
    PEVIEAADAA NVAMVATGMR HFRH 524
    Length:524
    Mass (Da):56,191
    Last modified:September 11, 2007 - v1
    Checksum:iB5BD1A674B490F9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS25606.1.
    RefSeqiWP_011985712.1. NC_009675.1.
    YP_001378590.1. NC_009675.1.

    Genome annotation databases

    EnsemblBacteriaiABS25606; ABS25606; Anae109_1399.
    GeneIDi5374120.
    KEGGiafw:Anae109_1399.
    PATRICi20927985. VBIAnaSp113478_1472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS25606.1 .
    RefSeqi WP_011985712.1. NC_009675.1.
    YP_001378590.1. NC_009675.1.

    3D structure databases

    ProteinModelPortali A7HA60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 404589.Anae109_1399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS25606 ; ABS25606 ; Anae109_1399 .
    GeneIDi 5374120.
    KEGGi afw:Anae109_1399.
    PATRICi 20927985. VBIAnaSp113478_1472.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi IRASSKN.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci ASP404589:GHMT-1408-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fw109-5.

    Entry informationi

    Entry nameiPUR9_ANADF
    AccessioniPrimary (citable) accession number: A7HA60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3