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A7HA60

- PUR9_ANADF

UniProt

A7HA60 - PUR9_ANADF

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciASP404589:GHMT-1408-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Anae109_1399
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
ProteomesiUP000006382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHPRO_1000018835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404589.Anae109_1399.

Structurei

3D structure databases

ProteinModelPortaliA7HA60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiIRASSKN.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HA60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRRALVSVS DKTGLVPFAK RLAALGVEIL STGGTQRALA DAGVPVVSVG
60 70 80 90 100
DYTQAPEILA GRVKTLHPRV HGGILYRRGL ASDEADVKAR DIPPIDLVVV
110 120 130 140 150
NLYPFREAVA AGKPFWDCVE EIDIGGPTMV RSAAKNAAHV GVVVDPADYE
160 170 180 190 200
RVAAELEASR ALSDQTRFEL MKKAFAHTAA YDAAISEFLT ARESTDAQAK
210 220 230 240 250
RFPATLAAVY SKAGDLRYGE NPHQAGAFYR AGREPDEPTV AFAKVLQGKE
260 270 280 290 300
LSYNNLLDLE AALAAVKEHD EVACVVIKHN TPCGVSLGKT PAEAFARARA
310 320 330 340 350
CDPVSAFGGI VALNRPVDAA AAKELTDLFL ECVIAPGYDE AARAALGAKK
360 370 380 390 400
NLRLLEAPRL AEPRTSWTRR PEELRELRSI PGGLLVMDRD LGAIRRDDCK
410 420 430 440 450
VMTKRAPTDA EWEDLLFAWK VVKHVKSNAI VFAKEKRTVG IGGGQTSRVE
460 470 480 490 500
SVKTAVMKAQ LELVGSTVGS DAFFPFKDGV EEIIKAGATA IIQPGGSVRD
510 520
PEVIEAADAA NVAMVATGMR HFRH
Length:524
Mass (Da):56,191
Last modified:September 11, 2007 - v1
Checksum:iB5BD1A674B490F9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS25606.1.
RefSeqiWP_011985712.1. NC_009675.1.
YP_001378590.1. NC_009675.1.

Genome annotation databases

EnsemblBacteriaiABS25606; ABS25606; Anae109_1399.
GeneIDi5374120.
KEGGiafw:Anae109_1399.
PATRICi20927985. VBIAnaSp113478_1472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS25606.1 .
RefSeqi WP_011985712.1. NC_009675.1.
YP_001378590.1. NC_009675.1.

3D structure databases

ProteinModelPortali A7HA60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404589.Anae109_1399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS25606 ; ABS25606 ; Anae109_1399 .
GeneIDi 5374120.
KEGGi afw:Anae109_1399.
PATRICi 20927985. VBIAnaSp113478_1472.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi IRASSKN.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ASP404589:GHMT-1408-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fw109-5.

Entry informationi

Entry nameiPUR9_ANADF
AccessioniPrimary (citable) accession number: A7HA60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3