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A7HA60

- PUR9_ANADF

UniProt

A7HA60 - PUR9_ANADF

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Anae109_1399
Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciASP404589:GHMT-1408-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Anae109_1399
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000006382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018835Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404589.Anae109_1399.

Structurei

3D structure databases

ProteinModelPortaliA7HA60.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiIRASSKN.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HA60-1 [UniParc]FASTAAdd to Basket

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MVRRALVSVS DKTGLVPFAK RLAALGVEIL STGGTQRALA DAGVPVVSVG    50
DYTQAPEILA GRVKTLHPRV HGGILYRRGL ASDEADVKAR DIPPIDLVVV 100
NLYPFREAVA AGKPFWDCVE EIDIGGPTMV RSAAKNAAHV GVVVDPADYE 150
RVAAELEASR ALSDQTRFEL MKKAFAHTAA YDAAISEFLT ARESTDAQAK 200
RFPATLAAVY SKAGDLRYGE NPHQAGAFYR AGREPDEPTV AFAKVLQGKE 250
LSYNNLLDLE AALAAVKEHD EVACVVIKHN TPCGVSLGKT PAEAFARARA 300
CDPVSAFGGI VALNRPVDAA AAKELTDLFL ECVIAPGYDE AARAALGAKK 350
NLRLLEAPRL AEPRTSWTRR PEELRELRSI PGGLLVMDRD LGAIRRDDCK 400
VMTKRAPTDA EWEDLLFAWK VVKHVKSNAI VFAKEKRTVG IGGGQTSRVE 450
SVKTAVMKAQ LELVGSTVGS DAFFPFKDGV EEIIKAGATA IIQPGGSVRD 500
PEVIEAADAA NVAMVATGMR HFRH 524
Length:524
Mass (Da):56,191
Last modified:September 11, 2007 - v1
Checksum:iB5BD1A674B490F9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS25606.1.
RefSeqiWP_011985712.1. NC_009675.1.
YP_001378590.1. NC_009675.1.

Genome annotation databases

EnsemblBacteriaiABS25606; ABS25606; Anae109_1399.
GeneIDi5374120.
KEGGiafw:Anae109_1399.
PATRICi20927985. VBIAnaSp113478_1472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS25606.1 .
RefSeqi WP_011985712.1. NC_009675.1.
YP_001378590.1. NC_009675.1.

3D structure databases

ProteinModelPortali A7HA60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404589.Anae109_1399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS25606 ; ABS25606 ; Anae109_1399 .
GeneIDi 5374120.
KEGGi afw:Anae109_1399.
PATRICi 20927985. VBIAnaSp113478_1472.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi IRASSKN.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ASP404589:GHMT-1408-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fw109-5.

Entry informationi

Entry nameiPUR9_ANADF
AccessioniPrimary (citable) accession number: A7HA60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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