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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciASP404589:G1G9J-1352-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Anae109_1319
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000151761 – 345S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST345

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi404589.Anae109_1319

Structurei

3D structure databases

ProteinModelPortaliA7H9Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004402
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

A7H9Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSDFDYEL PEELVAQEPV TPRDASRLLV LPREGAAEHR AFTDLPDLLA
60 70 80 90 100
PGDLLVFNDT KVIPARLVGT KPTGGKVELL LCEPLGGGLG SRWRAMGQAS
110 120 130 140 150
KPIREGTTLL FEGLEARVEA SEGEGFYVVT LDREGEALEA ALARAGRIPL
160 170 180 190 200
PPYIRRAPSD VDRERYQTIW ARAPGSAAAP TAGLHFTEAI LARLAARGVE
210 220 230 240 250
RTAVTLHVGP GTFLPVRGDS VEGHRMHAEQ YEVRPEAAAA IAACRARGSR
260 270 280 290 300
VVAVGTTSVR TLESAWRGGA VAAGAGRTAL FVRPGHAFRA VDALVTNFHL
310 320 330 340
PRSTLLMLVC AFGGTHRVLA AYRDAVARRY RFFSYGDAML LARAD
Length:345
Mass (Da):37,154
Last modified:September 11, 2007 - v1
Checksum:i17EE652232624A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS25527.1
RefSeqiWP_011985633.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS25527; ABS25527; Anae109_1319
KEGGiafw:Anae109_1319

Similar proteinsi

Entry informationi

Entry nameiQUEA_ANADF
AccessioniPrimary (citable) accession number: A7H9Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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