Reviewed, UniProtKB/Swiss-Prot A7H9E8 (DXS_ANADF)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	Anae109_1136

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019004

Sequences

	Sequence		Length	Mass (Da)
	A7H9E8-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 7E3417F9C6FCAFF1	FASTA	635	67,920
	10 20 30 40 50 60 MGRLLDSIDS PLDLKRLPVD DLPRLCEEIR EEIIQTCAKN GGHLGSSLGA VELNVALHYV 70 80 90 100 110 120 YSSPTDKLVW DVGHQAYAHK LLTGRRERFR TIRTEGGLAG FPERHESEHD AFGVGHASTA 130 140 150 160 170 180 ISAALGMLEA KRLSGAPGKV VALVGDGAMT GGVAFEGLNQ AGYLGRDLVV VLNDNEMSIS 190 200 210 220 230 240 PNVGALSEWF SKKFASRTYN RWRRAVKDFL SHVPKGPEAI DMIRHGINAT KALVTPGILF 250 260 270 280 290 300 EGLGFHYVGP VDGHDVRSLV ETLQKLVIFD GPVLLHAITT KGKGYQPAES DKATRGHGLS 310 320 330 340 350 360 FFDVATGKPV KKAAAKAYTD LFAEALCEEM ERDPRVVAIT AAMLEGTGLI KAKQRFPERT 370 380 390 400 410 420 YDVGIAEQHA VTFAAGLACE GVRPVVAIYS TFLQRAYDEI IHDVALQRLP VTFALDRGGL 430 440 450 460 470 480 VGADGKTHQG AFDVAYLRCV PNLVVMAPSD ENELRHMLHT ALHHDGPAAF RFPRGAGEGV 490 500 510 520 530 540 ALEAPQVLPI GKGRLARAVP GKPDVCVVAL GTTLHAALAA AEALAKDGVA ASVVDARFAK 550 560 570 580 590 600 PLDEELIAGE AERARCVVTI EEGCLPGGFG AACLELFERR GLVAEGLRVK RLGLPDEFVT 610 620 630 HGDQGRQRAQ LGLDADGIAR ACRAIVGERA KRGAA

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS25344.1.
RefSeq	YP_001378328.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7H9E8.
Genome annotation databases
GeneID	5375204.
GenomeReviews	Gene locus Anae109_1136 in contig CP000769_GR.
KEGG	afw:Anae109_1136.
NMPDR	fig|404589.4.peg.993.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ANADF

Accession

Primary (citable) accession number: A7H9E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)