Reviewed, UniProtKB/Swiss-Prot A7H9E0 (DCUP_ANADF)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Anae109_1128

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325622
Regions
	Region	23 – 27	5	Substrate binding By similarity
Sites
	Binding site	72	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	322	1	Substrate By similarity
	Site	72	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7H9E0-1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 37D81E41EE665B5B	FASTA	346	37,731
	10 20 30 40 50 60 MTHRFLEACR KQPVDRLPVW MMRQAGRYQP SYRAVRANVG FLELCRSPEL IAQVTVAPID 70 80 90 100 110 120 EFGFDAAILF SDILVHLPAM GLDLSFEKGE KGKGDGGPKI ANPVRTRADV DALKVPAPKK 130 140 150 160 170 180 DLPYVLDGVR AIRAALRDRV PLIGFVGGPF TVASYAVEGG SQGFTRLKTM LYAEPRTAHA 190 200 210 220 230 240 LFEKLTQAAI VQIEEQIAAG AQAAQIFESW LGELDRADLE EFAFPYLARI AEAVKRTGVP 250 260 270 280 290 300 SIFFSTGTTA HLEPISKLGY DVVSVDWRIP IDEARRRAPG VAIQGNMDST VLLGPKEVAV 310 320 330 340 ERALSIVRAA GREPGYIFNL GHGIQPGTPT ETVKAVVDAV HAFAWK

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS25336.1. Different initiation.
RefSeq	YP_001378320.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7H9E0.
Genome annotation databases
GeneID	5374078.
GenomeReviews	Gene locus Anae109_1128 in contig CP000769_GR.
KEGG	afw:Anae109_1128.
NMPDR	fig|404589.4.peg.985.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_ANADF

Accession

Primary (citable) accession number: A7H9E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	September 1, 2009
This is version 16 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)