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Reviewed, UniProtKB/Swiss-Prot A7H774 (DAPB_ANADF)

Last modified February 9, 2010. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26
Gene names
Name: dapB
Ordered Locus Names: Anae109_0355
OrganismAnaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]
Taxonomic identifier404589 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102

Subcellular location

Cytoplasm By similarity HAMAP MF_00102.

Sequence similarities

Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

dihydrodipicolinate reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Dihydrodipicolinate reductase HAMAP MF_00102
PRO_1000008533

Sequences

Sequence LengthMass (Da)Tools
A7H774-1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: E2AF684A7F713101

FASTA26827,509
        10         20         30         40         50         60 
MVNVVVTGAA GRMGTQIVRL VAAAEGLKLT GAVERPGHAG QDAGALAGIP PLGVAVVDDL 

        70         80         90        100        110        120 
AGALAGADVV IDFTSHEASA RNAELCAEKG VALVIGSTGF TPEAKARVAA AAARIPVVFS 

       130        140        150        160        170        180 
PNMSVGVNVL FELVRQAAKV LGDAYDVEIV EIHHKRKRDA PSGTAVALGE VAAGALGRDP 

       190        200        210        220        230        240 
ADALAYTRHG ILGERPPWQI GVQTLRGGDV VGEHTVYFCG EGERLELTHR ATSREQFARG 

       250        260 
AVRAAGFIAG KPAGLYDMAD VLGLRSAR 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. Fw109-5."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Lykidis A., Fields M., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000769 Genomic DNA. Translation: ABS24570.1.
RefSeqYP_001377554.1.

3D structure databases

SMRA7H774. Positions 2-266.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7H774.

Genome annotation databases

GeneID5374897.
GenomeReviewsGene locus Anae109_0355 in contig CP000769_GR.
KEGGafw:Anae109_0355.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0289.
HOGENOMHBG594002.
OMATIGFSTI.

Family and domain databases

HAMAPMF_00102. DapB.
[Tree]
InterProIPR000846. DapB.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR20836. DapB_bac/pln. 1 hit.
PfamPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00036. dapB. 1 hit.
PROSITEPS01298. DAPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ANADF
AccessionPrimary (citable) accession number: A7H774
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents