Reviewed, UniProtKB/Swiss-Prot A7H774 (DAPB_ANADF)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Anae109_0355

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008533

Sequences

	Sequence		Length	Mass (Da)
	A7H774-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: E2AF684A7F713101	FASTA	268	27,509
	10 20 30 40 50 60 MVNVVVTGAA GRMGTQIVRL VAAAEGLKLT GAVERPGHAG QDAGALAGIP PLGVAVVDDL 70 80 90 100 110 120 AGALAGADVV IDFTSHEASA RNAELCAEKG VALVIGSTGF TPEAKARVAA AAARIPVVFS 130 140 150 160 170 180 PNMSVGVNVL FELVRQAAKV LGDAYDVEIV EIHHKRKRDA PSGTAVALGE VAAGALGRDP 190 200 210 220 230 240 ADALAYTRHG ILGERPPWQI GVQTLRGGDV VGEHTVYFCG EGERLELTHR ATSREQFARG 250 260 AVRAAGFIAG KPAGLYDMAD VLGLRSAR

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000769 Genomic DNA. Translation: ABS24570.1.
RefSeq	YP_001377554.1.
3D structure databases
SMR	A7H774. Positions 2-266.
ModBase	Search...
Protein-protein interaction databases
STRING	A7H774.
Genome annotation databases
GeneID	5374897.
GenomeReviews	Gene locus Anae109_0355 in contig CP000769_GR.
KEGG	afw:Anae109_0355.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	TIGFSTI.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_ANADF

Accession

Primary (citable) accession number: A7H774

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)