A7H771 (ARLY_ANADF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Anae109_0352

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321427

Sequences

	Sequence		Length	Mass (Da)
	A7H771 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 1DFB764B8E632C12	FASTA	474	50,914
	10 20 30 40 50 60 MLASPPPMSA KTKSKPVSRA ALAGEADPRL VALSVSIQDD GALYAEDIRG SQAHVTMLAE 70 80 90 100 110 120 QGIVPKASAR RIVAALDQVR AEFAAGKIRL DPALEDVHTH VERRLGELVG ADAGYLHAGR 130 140 150 160 170 180 SRNDQVALDE RLFIVAACER CDAALGRLQR ALVARAREHE KTILPGYTHL QRAQPVSLAH 190 200 210 220 230 240 HLLAHVEAFA RDRDRLADVR RRAAVSPLGS GALAGTTLPL DREATAKALG LAGVTQNSLD 250 260 270 280 290 300 AVSDRDSAIE LLFACALAAV HLSRVGEEIV LWTTKEFGFM TLADAFATGS SLMPQKKNPD 310 320 330 340 350 360 VGELARGRAG RAIGDLVALL AIVKSLPLSY NRDMQEDKRP LIGGPDALVL TADAVGGAIE 370 380 390 400 410 420 TATFHADRME EALGSGEALA TDAAEYLVER GVPFREAHEA VGKAAAFSSA EGRPLAKLTA 430 440 450 460 470 DEWRRFHPAF QKDVLRCFDA RKSLARRELT GAPGPRQVAR QLARWEKALA KERR

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fw109-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000769 Genomic DNA. Translation: ABS24567.1.
RefSeq	YP_001377551.1. NC_009675.1.
3D structure databases
ProteinModelPortal	A7H771.
ModBase	Search...
Protein-protein interaction databases
STRING	A7H771.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5374894.
GenomeReviews	Gene locus Anae109_0352 in contig CP000769_GR.
KEGG	afw:Anae109_0352.
NMPDR	fig|404589.4.peg.319.
PATRIC	20925767. VBIAnaSp113478_0372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK00855.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANADF

Accession

Primary (citable) accession number: A7H771

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program