Reviewed, UniProtKB/Swiss-Prot A7H6U9 (PROA_ANADF)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	Anae109_0227

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Gamma-glutamyl phosphate reductase		PRO_1000049934

Sequences

	Sequence		Length	Mass (Da)
	A7H6U9-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 2D0D7CB63E8B5291	FASTA	428	44,800
	10 20 30 40 50 60 MRQPASEGLA AEMRRLAEAS SDASRALSRA QPRAKDEALR AAADAIGRRA KEILAASAED 70 80 90 100 110 120 VAAARAAGQS AAYLDRLALD PKRLDGIAAA LREVAALPDP VGEVTATWRR PNGLSVKKVR 130 140 150 160 170 180 IPLGVVLMVY EARPNVTVDA AALCVKSGNA AILRPGSDAL RSSLALAAAF AEGLAAAGLP 190 200 210 220 230 240 AASAQVVPTS DREATFELLQ LDDLIDLAIP RGGPSLIRAV AERSRVPVVK HYQGVCHLFL 250 260 270 280 290 300 DQSAPLQQAI DLALNGKVQR PAVCNALECL LVHREAAGRL LPAVGRALVD AGVELRSCPT 310 320 330 340 350 360 STTILARAGV PAVTAAPDDY GKEFSDLILA VRVVHDLDGA LDHIARYGSL HTEAILTRDL 370 380 390 400 410 420 ASARRFEREV TASAVMVNAS TRFNDGGELG LGAEIGISTT KLHAFGPMGL AELTTQKFVV EGDGQVRS

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS24445.1.
RefSeq	YP_001377429.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5376847.
GenomeReviews	Gene locus Anae109_0227 in contig CP000769_GR.
KEGG	afw:Anae109_0227.
NMPDR	fig|404589.4.peg.210.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DHase_C. IPR016162. Ald_DHase_N. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DHase. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_ANADF

Accession

Primary (citable) accession number: A7H6U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	November 25, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)