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A7H6N5 (UPPP_ANADF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Anae109_0163
OrganismAnaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]
Taxonomic identifier404589 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062786

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane54 – 7421Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7H6N5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 76D85EB3FBE0B8A8

FASTA30432,162
        10         20         30         40         50         60 
MSLLAAVFLG VLQAATEFLP VSSTAHLLVF GELLGHDLAD PRFRAFATII QTGTTLAVLV 

        70         80         90        100        110        120 
YFRTEILSLL AAGLRSLARR RPLETPQSRL AWFIVLGTVP AAVLGKLFEE RIEALGNWVI 

       130        140        150        160        170        180 
AGSLVVLGLV LLAAERYARH LRTVEDVGAR DAVLIGLGQA LALVPGSSRS GTTITAGMLL 

       190        200        210        220        230        240 
GFTREAAARF SFLLSVPIIL GAGGYKLWKT VPVLRGEPSW ALATLVGTAV SAVAGYLVID 

       250        260        270        280        290        300 
WLLGWLRTRT THLFVVWRIA AGVALAILIW QGVLPAGHAS VSAPAVEAAR AADPDAPLGA 


ALRR 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. Fw109-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Lykidis A., Fields M., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fw109-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000769 Genomic DNA. Translation: ABS24381.1.
RefSeqYP_001377365.1. NC_009675.1.

3D structure databases

ProteinModelPortalA7H6N5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING404589.Anae109_0163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS24381; ABS24381; Anae109_0163.
GeneID5377308.
KEGGafw:Anae109_0163.
PATRIC20925371. VBIAnaSp113478_0173.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWDKIMST.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycASP404589:GHMT-164-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ANADF
AccessionPrimary (citable) accession number: A7H6N5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families