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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciASP404589:G1G9J-167-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Anae109_0163
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei54 – 74HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000627861 – 304Undecaprenyl-diphosphataseAdd BLAST304

Proteomic databases

PRIDEiA7H6N5

Interactioni

Protein-protein interaction databases

STRINGi404589.Anae109_0163

Structurei

3D structure databases

ProteinModelPortaliA7H6N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

A7H6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLAAVFLG VLQAATEFLP VSSTAHLLVF GELLGHDLAD PRFRAFATII
60 70 80 90 100
QTGTTLAVLV YFRTEILSLL AAGLRSLARR RPLETPQSRL AWFIVLGTVP
110 120 130 140 150
AAVLGKLFEE RIEALGNWVI AGSLVVLGLV LLAAERYARH LRTVEDVGAR
160 170 180 190 200
DAVLIGLGQA LALVPGSSRS GTTITAGMLL GFTREAAARF SFLLSVPIIL
210 220 230 240 250
GAGGYKLWKT VPVLRGEPSW ALATLVGTAV SAVAGYLVID WLLGWLRTRT
260 270 280 290 300
THLFVVWRIA AGVALAILIW QGVLPAGHAS VSAPAVEAAR AADPDAPLGA

ALRR
Length:304
Mass (Da):32,162
Last modified:September 11, 2007 - v1
Checksum:i76D85EB3FBE0B8A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS24381.1
RefSeqiWP_011984487.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS24381; ABS24381; Anae109_0163
KEGGiafw:Anae109_0163

Similar proteinsi

Entry informationi

Entry nameiUPPP_ANADF
AccessioniPrimary (citable) accession number: A7H6N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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