Reviewed, UniProtKB/Swiss-Prot A7H6E5 (BIOD_ANADF)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase
    DTB synthetase
      Short name=DTBS

Gene names

Name:	bioD
Ordered Locus Names:	Anae109_0071

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Dethiobiotin synthetase HAMAP MF_00336		PRO_1000019547
Regions
	Nucleotide binding	8 – 16	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7H6E5-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: BBDB9A3C2C93CDCD	FASTA	223	23,146
	10 20 30 40 50 60 MRGLFITGTD TGVGKTEVTC ALVANARAAG LDAVPMKPAQ SGVAPGEPTD ADRLHAACDG 70 80 90 100 110 120 AEPLEVLCPY SFAAPLAPAV AARLEGRQVS FGAIVDGVRA LAARHEAVLV EGAGGLLVPL 130 140 150 160 170 180 TEEETYADLA VALGLSVLVV ARAGLGTVNH TALTVEALRA RGLVLTAIVL NQACETDDPS 190 200 210 220 VPYNPAEIAR VTGREPLARL AHVRDIAERQ RFLRSRLAGK IQF

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS24291.1.
RefSeq	YP_001377275.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7H6E5.
Genome annotation databases
GeneID	5378237.
GenomeReviews	Gene locus Anae109_0071 in contig CP000769_GR.
KEGG	afw:Anae109_0071.
NMPDR	fig|404589.4.peg.67.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CLIEGAG.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD_ANADF

Accession

Primary (citable) accession number: A7H6E5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)