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A7H5E3 (A7H5E3_CAMJD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoheptose isomerase HAMAP-Rule MF_00067
EC=5.3.1.28 HAMAP-Rule MF_00067
Alternative name(s):
Sedoheptulose 7-phosphate isomerase HAMAP-Rule MF_00067
Gene names
Name:gmhA HAMAP-Rule MF_00067 EMBL ABS44186.1
Ordered Locus Names:JJD26997_1756
OrganismCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97) [Complete proteome] [HAMAP] EMBL ABS44186.1
Taxonomic identifier360109 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter ›

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. SAAS SAAS004515 HAMAP-Rule MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS004515 HAMAP-Rule MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. SAAS SAAS004515 HAMAP-Rule MF_00067

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00067

Subcellular location

Cytoplasm By similarity SAAS SAAS004515 HAMAP-Rule MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP-Rule MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily. HAMAP-Rule MF_00067

Contains 1 SIS domain. SAAS SAAS004515 HAMAP-Rule MF_00067

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain36 – 195160SIS By similarity HAMAP-Rule MF_00067
Region51 – 533Substrate binding By similarity HAMAP-Rule MF_00067
Region93 – 942Substrate binding By similarity HAMAP-Rule MF_00067
Region119 – 1213Substrate binding By similarity HAMAP-Rule MF_00067

Sites

Metal binding601Zinc By similarity HAMAP-Rule MF_00067
Metal binding641Zinc By similarity HAMAP-Rule MF_00067
Metal binding1711Zinc By similarity HAMAP-Rule MF_00067
Metal binding1791Zinc By similarity HAMAP-Rule MF_00067
Binding site641Substrate By similarity HAMAP-Rule MF_00067
Binding site1241Substrate By similarity HAMAP-Rule MF_00067
Binding site1711Substrate By similarity HAMAP-Rule MF_00067

Sequences

Sequence LengthMass (Da)Tools
A7H5E3 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: D434434C5F7E4C13

FASTA19821,321
        10         20         30         40         50         60 
MVNYIKEHFT DSILVKEQIL KDENLITLIK NASLEVIKAY KKGNKTLLAG NGGSAADAQH 

        70         80         90        100        110        120 
IAGEFVSRFY FDRPGIASIA LSTDTSILTA ISNDYGYENL FARQVQAQGV SGDVFIGIST 

       130        140        150        160        170        180 
SGNSKNILKA LEICKEKGIL SIGLSGANGG AMNELCDYCI KVPSTCTPRI QEAHILIGHI 

       190 
ICAIVEEELF GKGFSCKQ

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References

[1]"Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1458 / RM4099 / 269.97.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000768 Genomic DNA. Translation: ABS44186.1.
RefSeqYP_001398723.1. NC_009707.1.

3D structure databases

ProteinModelPortalA7H5E3.
ModBaseSearch...

Protein-protein interaction databases

STRING360109.JJD26997_1756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS44186; ABS44186; JJD26997_1756.
GeneID5390311.
KEGGcjd:JJD26997_1756.
PATRIC20049192. VBICamJej122183_1740.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0279.
HOGENOMHOG000237571.
KOK03271.
OMAAYSTSGK.
ProtClustDBCLSK879250.

Enzyme and pathway databases

BioCycCJEJ360109:GJDG-1706-MONOMER.
UniPathwayUPA00041; UER00436.

Family and domain databases

HAMAPMF_00067. GmhA.
InterProIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamPF13580. SIS_2. 1 hit.
[Graphical view]
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7H5E3_CAMJD
AccessionPrimary (citable) accession number: A7H5E3
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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