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Protein

NAD kinase

Gene

nadK

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton acceptorUniRule annotation1
Binding sitei178NADUniRule annotation1
Binding sitei186NAD; via carbonyl oxygenUniRule annotation1
Binding sitei244NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 75NADUniRule annotation2
Nucleotide bindingi148 – 149NADUniRule annotation2
Nucleotide bindingi189 – 194NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ360109:G1G9I-1273-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:JJD26997_1358
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002302 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000053991 – 286NAD kinaseAdd BLAST286

Structurei

3D structure databases

ProteinModelPortaliA7H4H1
SMRiA7H4H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.301 hit
3.40.50.103302 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A7H4H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNKIDHKNI KKIGLVTRPN VSLDKEILKL QSILSIYKVE LVLFKESSEI
60 70 80 90 100
LDLPKYGLDD LFKISDFVIS LGGDGTLISL CRKACEYDKA VLGIHAGHLG
110 120 130 140 150
FLTDFKVDEA ENFFQAFFQG EFRIEKPYLL SVFLEDKQGK ILEKLAFNDV
160 170 180 190 200
VISKNNQAPM AHIEVFRKEK KFNEYFGDGL IVATPAGSTA YNLSANGPIV
210 220 230 240 250
YTLAQAFILT PVCSHSLTQR SIVLPKGFEI EIMAKDCILC IDGQENYKMN
260 270 280
DFKSIKVGLS DKNVALIHPK NRDYFQILKE KLHWGN
Length:286
Mass (Da):32,330
Last modified:September 11, 2007 - v1
Checksum:i16A05217B9D67B2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA Translation: ABS44357.1

Genome annotation databases

EnsemblBacteriaiABS44357; ABS44357; JJD26997_1358
KEGGicjd:JJD26997_1358

Similar proteinsi

Entry informationi

Entry nameiNADK_CAMJD
AccessioniPrimary (citable) accession number: A7H4H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome