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A7H4H1

- NADK_CAMJD

UniProt

A7H4H1 - NADK_CAMJD

Protein

NAD kinase

Gene

nadK

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Proton acceptorUniRule annotation
    Binding sitei178 – 1781NADUniRule annotation
    Binding sitei186 – 1861NAD; via carbonyl oxygenUniRule annotation
    Binding sitei244 – 2441NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 752NADUniRule annotation
    Nucleotide bindingi148 – 1492NADUniRule annotation
    Nucleotide bindingi189 – 1946NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEJ360109:GJDG-1319-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:JJD26997_1358
    OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
    Taxonomic identifieri360109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002302: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286NAD kinasePRO_1000005399Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360109.JJD26997_1358.

    Structurei

    3D structure databases

    ProteinModelPortaliA7H4H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiHPSIPGW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7H4H1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNKIDHKNI KKIGLVTRPN VSLDKEILKL QSILSIYKVE LVLFKESSEI    50
    LDLPKYGLDD LFKISDFVIS LGGDGTLISL CRKACEYDKA VLGIHAGHLG 100
    FLTDFKVDEA ENFFQAFFQG EFRIEKPYLL SVFLEDKQGK ILEKLAFNDV 150
    VISKNNQAPM AHIEVFRKEK KFNEYFGDGL IVATPAGSTA YNLSANGPIV 200
    YTLAQAFILT PVCSHSLTQR SIVLPKGFEI EIMAKDCILC IDGQENYKMN 250
    DFKSIKVGLS DKNVALIHPK NRDYFQILKE KLHWGN 286
    Length:286
    Mass (Da):32,330
    Last modified:September 11, 2007 - v1
    Checksum:i16A05217B9D67B2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000768 Genomic DNA. Translation: ABS44357.1.
    RefSeqiYP_001398401.1. NC_009707.1.

    Genome annotation databases

    EnsemblBacteriaiABS44357; ABS44357; JJD26997_1358.
    GeneIDi5389434.
    KEGGicjd:JJD26997_1358.
    PATRICi20048390. VBICamJej122183_1350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000768 Genomic DNA. Translation: ABS44357.1 .
    RefSeqi YP_001398401.1. NC_009707.1.

    3D structure databases

    ProteinModelPortali A7H4H1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360109.JJD26997_1358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS44357 ; ABS44357 ; JJD26997_1358 .
    GeneIDi 5389434.
    KEGGi cjd:JJD26997_1358.
    PATRICi 20048390. VBICamJej122183_1350.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi HPSIPGW.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CJEJ360109:GJDG-1319-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1458 / RM4099 / 269.97.

    Entry informationi

    Entry nameiNADK_CAMJD
    AccessioniPrimary (citable) accession number: A7H4H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3