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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCJEJ360109:GJDG-1051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:JJD26997_1088
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002302 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156RNA pyrophosphohydrolasePRO_1000078957Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7H3U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 148143Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 6422Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000066722.
KOiK08311.
OMAiERNEVFW.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7H3U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENEKNYRPN VAAIVLSSSY PFECKIFIAK RSDMDNIWQF PQGGIDKGES
60 70 80 90 100
AKNALFRELK EEIGTDEVEI IAEYPEWLSY DFPGKIVKKM YPYDGQIQKY
110 120 130 140 150
FLVRLKHGAT ININTKHPEF DDYQFVSVKQ IFEMINHFKK NIYVKVIKYF

EEKGYI
Length:156
Mass (Da):18,470
Last modified:September 11, 2007 - v1
Checksum:iD2C27C4D8E2680B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA. Translation: ABS44569.1.
RefSeqiWP_011990267.1. NC_009707.1.

Genome annotation databases

EnsemblBacteriaiABS44569; ABS44569; JJD26997_1088.
KEGGicjd:JJD26997_1088.
PATRICi20047839. VBICamJej122183_1089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA. Translation: ABS44569.1.
RefSeqiWP_011990267.1. NC_009707.1.

3D structure databases

ProteinModelPortaliA7H3U9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS44569; ABS44569; JJD26997_1088.
KEGGicjd:JJD26997_1088.
PATRICi20047839. VBICamJej122183_1089.

Phylogenomic databases

HOGENOMiHOG000066722.
KOiK08311.
OMAiERNEVFW.
OrthoDBiEOG6Q2SKR.

Enzyme and pathway databases

BioCyciCJEJ360109:GJDG-1051-MONOMER.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1458 / RM4099 / 269.97.

Entry informationi

Entry nameiRPPH_CAMJD
AccessioniPrimary (citable) accession number: A7H3U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 11, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.