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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei582ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ360109:G1G9I-589-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:JJD26997_0632
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002302 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093171 – 809Leucine--tRNA ligaseAdd BLAST809

Structurei

3D structure databases

ProteinModelPortaliA7H2R6
SMRiA7H2R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionAdd BLAST11
Motifi579 – 583"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7H2R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYEASLIEK KWQKIWDENE YFEPKDDLNL PKKYILSMFP YPSGRIHMGH
60 70 80 90 100
VRNYTIGDAL ARYYRKIGFN VLHPIGFDSF GMPAENAAIK HKIHPKSWTY
110 120 130 140 150
ENIAYMKKEL FSLGFSFSKK RMLATSDPLY TKFEQEIFIK MFEKGLIYTK
160 170 180 190 200
EANVNWCEQD QTVLANEQVE DGKCWRCGHE VVQKKMPGYY VKITAYAEKL
210 220 230 240 250
LKDLEGLRDK WPNQVLTMQE NWIGKSEGLA FSLNLDEKSK QKAKESSLEV
260 270 280 290 300
FTTRADTIYG VSYVALAPEH KIVQNLLLQN LLNQDVLNKI KAIQNQSPRE
310 320 330 340 350
RQSSEKEGYF LGIYAIHPLS GEKIPLWVAN FVLSDYGSGA VMAVPAHDER
360 370 380 390 400
DFEFAKKYNL AIKQVIQTQE NLPYTQKLGK LIHSQEFDNL DCNEARLKII
410 420 430 440 450
SQFEAKNIGK RVVNFKIRDW GVSRQRYWGA PIPMIKCQSC GIAPQKLENL
460 470 480 490 500
PITLPEDVQI TGEGNPLDKH PTWKNCICPK CGKEAQKESD TLDTFFESSW
510 520 530 540 550
YFARFASDEK TWQEKALDEK SVKYWMSVDQ YIGGIEHAIL HLLYARFFQK
560 570 580 590 600
ALRDLGYLTQ NEPFDRLLTQ GMVLKDGAKM SKSKGNVVDP DEIIEKYGAD
610 620 630 640 650
TARLFMLFAA PPAKELEWND DAVEGAYRFI CKLYDRAQNI KKGELVELKQ
660 670 680 690 700
ENLNKEEKYA RLKVYEALKK SEEVYHQSFA FNTLIAACME ALNALALCKN
710 720 730 740 750
EALEQEAFYI ILNILEPIIP HVCFELSEEL FKCKNFKKLE LKEEVFVKDT
760 770 780 790 800
LNLAVSINGK KRAEFKISSS ASKEEILAFA KENTAKWLEG KSIVKEIYVE

GKLVNLVIK
Length:809
Mass (Da):93,268
Last modified:September 11, 2007 - v1
Checksum:iC537E7C634CEE377
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA Translation: ABS43284.1

Genome annotation databases

EnsemblBacteriaiABS43284; ABS43284; JJD26997_0632
KEGGicjd:JJD26997_0632

Similar proteinsi

Entry informationi

Entry nameiSYL_CAMJD
AccessioniPrimary (citable) accession number: A7H2R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health