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A7H2R6

- SYL_CAMJD

UniProt

A7H2R6 - SYL_CAMJD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei582 – 5821ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCJEJ360109:GJDG-611-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:JJD26997_0632
    OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
    Taxonomic identifieri360109 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002302: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Leucine--tRNA ligasePRO_1000009317Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360109.JJD26997_0632.

    Structurei

    3D structure databases

    ProteinModelPortaliA7H2R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi579 – 5835"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7H2R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYEASLIEK KWQKIWDENE YFEPKDDLNL PKKYILSMFP YPSGRIHMGH    50
    VRNYTIGDAL ARYYRKIGFN VLHPIGFDSF GMPAENAAIK HKIHPKSWTY 100
    ENIAYMKKEL FSLGFSFSKK RMLATSDPLY TKFEQEIFIK MFEKGLIYTK 150
    EANVNWCEQD QTVLANEQVE DGKCWRCGHE VVQKKMPGYY VKITAYAEKL 200
    LKDLEGLRDK WPNQVLTMQE NWIGKSEGLA FSLNLDEKSK QKAKESSLEV 250
    FTTRADTIYG VSYVALAPEH KIVQNLLLQN LLNQDVLNKI KAIQNQSPRE 300
    RQSSEKEGYF LGIYAIHPLS GEKIPLWVAN FVLSDYGSGA VMAVPAHDER 350
    DFEFAKKYNL AIKQVIQTQE NLPYTQKLGK LIHSQEFDNL DCNEARLKII 400
    SQFEAKNIGK RVVNFKIRDW GVSRQRYWGA PIPMIKCQSC GIAPQKLENL 450
    PITLPEDVQI TGEGNPLDKH PTWKNCICPK CGKEAQKESD TLDTFFESSW 500
    YFARFASDEK TWQEKALDEK SVKYWMSVDQ YIGGIEHAIL HLLYARFFQK 550
    ALRDLGYLTQ NEPFDRLLTQ GMVLKDGAKM SKSKGNVVDP DEIIEKYGAD 600
    TARLFMLFAA PPAKELEWND DAVEGAYRFI CKLYDRAQNI KKGELVELKQ 650
    ENLNKEEKYA RLKVYEALKK SEEVYHQSFA FNTLIAACME ALNALALCKN 700
    EALEQEAFYI ILNILEPIIP HVCFELSEEL FKCKNFKKLE LKEEVFVKDT 750
    LNLAVSINGK KRAEFKISSS ASKEEILAFA KENTAKWLEG KSIVKEIYVE 800
    GKLVNLVIK 809
    Length:809
    Mass (Da):93,268
    Last modified:September 11, 2007 - v1
    Checksum:iC537E7C634CEE377
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000768 Genomic DNA. Translation: ABS43284.1.
    RefSeqiWP_011989907.1. NC_009707.1.
    YP_001397796.1. NC_009707.1.

    Genome annotation databases

    EnsemblBacteriaiABS43284; ABS43284; JJD26997_0632.
    GeneIDi5390226.
    KEGGicjd:JJD26997_0632.
    PATRICi20046911. VBICamJej122183_0629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000768 Genomic DNA. Translation: ABS43284.1 .
    RefSeqi WP_011989907.1. NC_009707.1.
    YP_001397796.1. NC_009707.1.

    3D structure databases

    ProteinModelPortali A7H2R6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360109.JJD26997_0632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS43284 ; ABS43284 ; JJD26997_0632 .
    GeneIDi 5390226.
    KEGGi cjd:JJD26997_0632.
    PATRICi 20046911. VBICamJej122183_0629.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CJEJ360109:GJDG-611-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1458 / RM4099 / 269.97.

    Entry informationi

    Entry nameiSYL_CAMJD
    AccessioniPrimary (citable) accession number: A7H2R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3