A7H2Q9 (PYRB_CAMJD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	JJD26997_0624

Organism

Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97) [Complete proteome] [HAMAP]

Taxonomic identifier

360109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000000004

Sequences

	Sequence		Length	Mass (Da)
	A7H2Q9 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: D034DC882C635832	FASTA	295	33,205
	10 20 30 40 50 60 MRHLITTKDF NKIEIMELFK EASDFLDEKP RTFLEGKSIT TIFFENSTRT LSSFESAARR 70 80 90 100 110 120 LGARVLRLDV SRSSSSKGET LYDTAANLDA MSPNAIVVRH ANSGVPLILA KHMHCPVVNG 130 140 150 160 170 180 GDGKHAHPTQ ALLDLFTIYN HFQSDVEGKK ICIVGDIKNS RVAASNIELL SRFNLDITLV 190 200 210 220 230 240 APPHFMPNTH LKKYYKLDEN IIANSDIIMS LRTQTERHNK TVYASLKDYA NDFCIQKSLV 250 260 270 280 290 KDKKLILLHP GPVNRNIDIS DEMMSDERTL VLKQVKNGVA IRMAVLKKLI LENEG

References

[1]

"Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1458 / RM4099 / 269.97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000768 Genomic DNA. Translation: ABS44816.1.
RefSeq	YP_001397789.1. NC_009707.1.
3D structure databases
ProteinModelPortal	A7H2Q9.
ModBase	Search...
Protein-protein interaction databases
STRING	A7H2Q9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5388785.
GenomeReviews	Gene locus JJD26997_0624 in contig CP000768_GR.
KEGG	cjd:JJD26997_0624.
PATRIC	20046895. VBICamJej122183_0621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	CJEJ360109:JJD26997_0624-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_CAMJD

Accession

Primary (citable) accession number: A7H2Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program