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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi506MagnesiumUniRule annotation1
Metal bindingi512MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ360109:G1G9I-436-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:JJD26997_0472
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295731 – 718Polyribonucleotide nucleotidyltransferaseAdd BLAST718

Structurei

3D structure databases

ProteinModelPortaliA7H2C7
SMRiA7H2C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini572 – 632KHUniRule annotationAdd BLAST61
Domaini657 – 718S1 motifUniRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 2 hits
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A7H2C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYSIEINKN TEIFDIDKVA KQATGVLMRQ GKSVVLATVA REEKQVEEDF
60 70 80 90 100
LPLTVQYIEK AYAAGKIPGG YVKRETKPSD AETLTARIID RSLRPLFPKG
110 120 130 140 150
YAYPTQIVVM VLSADPKVDL QVMSLNAASV ALYLSDIPMK APVCGVRIGK
160 170 180 190 200
IDGNFILNPN NEELQNSTLD LYVAGVKDEL LMIEMRALPD QKENEIFIEA
210 220 230 240 250
PYADVLTQTT SQNMNELSED EILEALNLAQ KAILNGSNAY EEAFSKHKKN
260 270 280 290 300
SQIELKNEIE HPEILAFIEN NFQKQIKKAI NQMAKSERAS ELNKIAKEIL
310 320 330 340 350
NLEIAKDWSE ESILNTLAKV KRKLIREQIL NEGKRADGRS LNEVRPISIE
360 370 380 390 400
TNILPNAHGS CLFTRGQTQA LVVATLGGEN DAQMIDLLTE KNPISERFMV
410 420 430 440 450
NYNFPGFSVG EASPIKAPGR RELGHGNLAK RALYPSVDEN YPYVIRLVSE
460 470 480 490 500
ILESNGSSSM ATVCGGSLAL KAAGVPSLKL VAGVAMGLIF EDNKYAVLTD
510 520 530 540 550
IMGLEDHDGD MDFKVAGSKD GITALQMDIK LGGIDQETLK QALYQAKEGR
560 570 580 590 600
IHILNIMEEA TKEIIVNEEV LPKLELFSVD PSKIVDIIGQ AGKTIKEIIE
610 620 630 640 650
KFGVSIDLDR EKGEVKIAGS QNEQIKAAKD YIINITSSQK GTKKGSKDKD
660 670 680 690 700
ISDFELGQEF QGIVKKIAPF GAFVELKNGV DGLLHSSKIK HLDLSENQSL
710
KVKISEIKNG KISVDLCE
Length:718
Mass (Da):79,192
Last modified:September 11, 2007 - v1
Checksum:i74C08B97A49E2A31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA Translation: ABS44081.1

Genome annotation databases

EnsemblBacteriaiABS44081; ABS44081; JJD26997_0472
KEGGicjd:JJD26997_0472

Entry informationi

Entry nameiPNP_CAMJD
AccessioniPrimary (citable) accession number: A7H2C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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