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A7H2C7

- PNP_CAMJD

UniProt

A7H2C7 - PNP_CAMJD

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi506 – 5061MagnesiumUniRule annotation
Metal bindingi512 – 5121MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCJEJ360109:GJDG-454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:JJD26997_0472
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000002302: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Polyribonucleotide nucleotidyltransferasePRO_0000329573Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360109.JJD26997_0472.

Structurei

3D structure databases

ProteinModelPortaliA7H2C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini572 – 63261KHUniRule annotationAdd
BLAST
Domaini657 – 71862S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7H2C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYSIEINKN TEIFDIDKVA KQATGVLMRQ GKSVVLATVA REEKQVEEDF
60 70 80 90 100
LPLTVQYIEK AYAAGKIPGG YVKRETKPSD AETLTARIID RSLRPLFPKG
110 120 130 140 150
YAYPTQIVVM VLSADPKVDL QVMSLNAASV ALYLSDIPMK APVCGVRIGK
160 170 180 190 200
IDGNFILNPN NEELQNSTLD LYVAGVKDEL LMIEMRALPD QKENEIFIEA
210 220 230 240 250
PYADVLTQTT SQNMNELSED EILEALNLAQ KAILNGSNAY EEAFSKHKKN
260 270 280 290 300
SQIELKNEIE HPEILAFIEN NFQKQIKKAI NQMAKSERAS ELNKIAKEIL
310 320 330 340 350
NLEIAKDWSE ESILNTLAKV KRKLIREQIL NEGKRADGRS LNEVRPISIE
360 370 380 390 400
TNILPNAHGS CLFTRGQTQA LVVATLGGEN DAQMIDLLTE KNPISERFMV
410 420 430 440 450
NYNFPGFSVG EASPIKAPGR RELGHGNLAK RALYPSVDEN YPYVIRLVSE
460 470 480 490 500
ILESNGSSSM ATVCGGSLAL KAAGVPSLKL VAGVAMGLIF EDNKYAVLTD
510 520 530 540 550
IMGLEDHDGD MDFKVAGSKD GITALQMDIK LGGIDQETLK QALYQAKEGR
560 570 580 590 600
IHILNIMEEA TKEIIVNEEV LPKLELFSVD PSKIVDIIGQ AGKTIKEIIE
610 620 630 640 650
KFGVSIDLDR EKGEVKIAGS QNEQIKAAKD YIINITSSQK GTKKGSKDKD
660 670 680 690 700
ISDFELGQEF QGIVKKIAPF GAFVELKNGV DGLLHSSKIK HLDLSENQSL
710
KVKISEIKNG KISVDLCE
Length:718
Mass (Da):79,192
Last modified:September 11, 2007 - v1
Checksum:i74C08B97A49E2A31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000768 Genomic DNA. Translation: ABS44081.1.
RefSeqiYP_001397657.1. NC_009707.1.

Genome annotation databases

EnsemblBacteriaiABS44081; ABS44081; JJD26997_0472.
GeneIDi5388770.
KEGGicjd:JJD26997_0472.
PATRICi20046579. VBICamJej122183_0464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000768 Genomic DNA. Translation: ABS44081.1 .
RefSeqi YP_001397657.1. NC_009707.1.

3D structure databases

ProteinModelPortali A7H2C7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360109.JJD26997_0472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS44081 ; ABS44081 ; JJD26997_0472 .
GeneIDi 5388770.
KEGGi cjd:JJD26997_0472.
PATRICi 20046579. VBICamJej122183_0464.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CJEJ360109:GJDG-454-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1458 / RM4099 / 269.97.

Entry informationi

Entry nameiPNP_CAMJD
AccessioniPrimary (citable) accession number: A7H2C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3