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A7H2A2

- TRMB_CAMJD

UniProt

A7H2A2 - TRMB_CAMJD

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231S-adenosyl-L-methionineUniRule annotation
Binding sitei148 – 1481S-adenosyl-L-methionineUniRule annotation
Binding sitei175 – 1751S-adenosyl-L-methionineUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei231 – 2311SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCJEJ360109:GJDG-429-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:JJD26997_0447
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000002302: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392tRNA (guanine-N(7)-)-methyltransferasePRO_1000064389Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360109.JJD26997_0447.

Structurei

3D structure databases

ProteinModelPortaliA7H2A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000252163.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7H2A2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNFKSKKIK EINLPYSKDD VEFLWFAKND NVSLIYTKVQ EESFFLQIKK
60 70 80 90 100
AQNGFVIKGD KHTKPSKIGY LQKALKIFKE GFCEDIINEA FGLKNNALIE
110 120 130 140 150
KTPFIVDNFD ELLSKLQGKI YIEIGFGSGR HLLYQAKENP NVLILGVEIY
160 170 180 190 200
NPALTQVAKL AKAQNVNNIL LIQSDARLLL SVLKSKSVEK IFLHFPVPWG
210 220 230 240 250
KKPHRRVIGK DFCKECARVL VQNGRFELRT DSFEYFNFTL EQFLTFPAPK
260 270 280 290 300
FSLRKNENLE ISSKYEDRWK KQEKNIYDLW VWNFNQECQN YELNEFNLSS
310 320 330 340 350
VEFSKEDLKK IEQNFKNITI KKDDFFLHFE SIYKQDENLL LKVAFGAFNK
360 370 380 390
SEHCYLHLDK TIDFAFKEPF KIQENIKAIN ELKEILKVQF KI
Length:392
Mass (Da):46,122
Last modified:September 11, 2007 - v1
Checksum:i00A2DEA6647C5764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA. Translation: ABS43838.1.
RefSeqiWP_011989759.1. NC_009707.1.
YP_001397632.1. NC_009707.1.

Genome annotation databases

EnsemblBacteriaiABS43838; ABS43838; JJD26997_0447.
GeneIDi5389147.
KEGGicjd:JJD26997_0447.
PATRICi20046529. VBICamJej122183_0439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA. Translation: ABS43838.1 .
RefSeqi WP_011989759.1. NC_009707.1.
YP_001397632.1. NC_009707.1.

3D structure databases

ProteinModelPortali A7H2A2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360109.JJD26997_0447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS43838 ; ABS43838 ; JJD26997_0447 .
GeneIDi 5389147.
KEGGi cjd:JJD26997_0447.
PATRICi 20046529. VBICamJej122183_0439.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000252163.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CJEJ360109:GJDG-429-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1458 / RM4099 / 269.97.

Entry informationi

Entry nameiTRMB_CAMJD
AccessioniPrimary (citable) accession number: A7H2A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3