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A7H2A2

- TRMB_CAMJD

UniProt

A7H2A2 - TRMB_CAMJD

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, JJD26997_0447
Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Binding sitei148 – 1481S-adenosyl-L-methionine By similarity
Binding sitei175 – 1751S-adenosyl-L-methionine By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei231 – 2311Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCJEJ360109:GJDG-429-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:JJD26997_0447
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000002302: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000064389Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360109.JJD26997_0447.

Structurei

3D structure databases

ProteinModelPortaliA7H2A2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000252163.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7H2A2-1 [UniParc]FASTAAdd to Basket

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MPNFKSKKIK EINLPYSKDD VEFLWFAKND NVSLIYTKVQ EESFFLQIKK    50
AQNGFVIKGD KHTKPSKIGY LQKALKIFKE GFCEDIINEA FGLKNNALIE 100
KTPFIVDNFD ELLSKLQGKI YIEIGFGSGR HLLYQAKENP NVLILGVEIY 150
NPALTQVAKL AKAQNVNNIL LIQSDARLLL SVLKSKSVEK IFLHFPVPWG 200
KKPHRRVIGK DFCKECARVL VQNGRFELRT DSFEYFNFTL EQFLTFPAPK 250
FSLRKNENLE ISSKYEDRWK KQEKNIYDLW VWNFNQECQN YELNEFNLSS 300
VEFSKEDLKK IEQNFKNITI KKDDFFLHFE SIYKQDENLL LKVAFGAFNK 350
SEHCYLHLDK TIDFAFKEPF KIQENIKAIN ELKEILKVQF KI 392
Length:392
Mass (Da):46,122
Last modified:September 11, 2007 - v1
Checksum:i00A2DEA6647C5764
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000768 Genomic DNA. Translation: ABS43838.1.
RefSeqiYP_001397632.1. NC_009707.1.

Genome annotation databases

EnsemblBacteriaiABS43838; ABS43838; JJD26997_0447.
GeneIDi5389147.
KEGGicjd:JJD26997_0447.
PATRICi20046529. VBICamJej122183_0439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000768 Genomic DNA. Translation: ABS43838.1 .
RefSeqi YP_001397632.1. NC_009707.1.

3D structure databases

ProteinModelPortali A7H2A2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360109.JJD26997_0447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS43838 ; ABS43838 ; JJD26997_0447 .
GeneIDi 5389147.
KEGGi cjd:JJD26997_0447.
PATRICi 20046529. VBICamJej122183_0439.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000252163.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CJEJ360109:GJDG-429-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1458 / RM4099 / 269.97.

Entry informationi

Entry nameiTRMB_CAMJD
AccessioniPrimary (citable) accession number: A7H2A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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