Reviewed, UniProtKB/Swiss-Prot A7H243 (DXR_CAMJD)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

Name:	dxr
Ordered Locus Names:	JJD26997_0364

Organism

Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97) [Complete proteome] [HAMAP]

Taxonomic identifier

360109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.
Catalytic activity	2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183
Cofactor	Divalent cation By similarity.
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183
Sequence similarities	Belongs to the DXR family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Ligand	Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183		PRO_1000020239
Regions
	Nucleotide binding	4 – 30	27	NADP By similarity
Sites
	Metal binding	131	1	Divalent metal cation By similarity
	Metal binding	133	1	Divalent metal cation By similarity
	Metal binding	200	1	Divalent metal cation By similarity
	Binding site	112	1	Substrate By similarity
	Binding site	133	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	178	1	Substrate By similarity
	Binding site	200	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7H243-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: A7A55E93791DAE9A	FASTA	356	39,521
	10 20 30 40 50 60 MILFGSTGSI GVNALKLAAL KNIPISALAC GDNIALLNEQ IARFKPQFVA IKDSKNKHLV 70 80 90 100 110 120 KHDRVFIGQE GLEQILTECQ DRLLLNAIVG FAGLKSTLKA KELGKNIALA NKESLVVAGS 130 140 150 160 170 180 FLKGAKFLPI DSEHVALKFL LEGKKNIAKL YITASGGAFY KYKIKDLNQV SVKDALKHPN 190 200 210 220 230 240 WNMGAKITID SATMANKLFE IIEAYHLYDF KESDALIEPR SLVHAMCEFK NGASTAYFSK 250 260 270 280 290 300 ADMKLAISDA IFEKQDTPIL EAVDFSKMPA LKFHKISTKK YPIFKLKNAF LKEPNLGVII 310 320 330 340 350 NAANEVGVYN FLENKSGFLD IAQCIFKALD HFGAPKISSI EEVFEYDFKT REYLRS

References

[1]

"Complete genome sequence of Campylobacter jejuni subsp doylei 269.97 isolated from human blood." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000768 Genomic DNA. Translation: ABS43260.1.
RefSeq	YP_001397573.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7H243.
Genome annotation databases
GeneID	5390301.
GenomeReviews	Gene locus JJD26997_0364 in contig CP000768_GR.
KEGG	cjd:JJD26997_0364.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IHSMVEY.
Family and domain databases
HAMAP	MF_00183. [Tree]
InterPro	IPR003821. DXP_reductoisomerase. IPR013644. DXP_reductoisomerase_C. IPR013512. DXP_reductoisomerase_N. [Graphical view]
Pfam	PF08436. DXP_redisom_C. 1 hit. PF02670. DXP_reductoisom. 1 hit. [Graphical view]
PIRSF	PIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMs	TIGR00243. Dxr. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DXR_CAMJD

Accession

Primary (citable) accession number: A7H243

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)