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Protein

Adenylosuccinate lyase

Gene

purB-1

Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (purB-1)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB-1)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCJEJ360109:G1G9I-24-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purB-1Imported
Ordered Locus Names:JJD26997_0025Imported
OrganismiCampylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)Imported
Taxonomic identifieri360109 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002302 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA7H1B3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 441ADSL_CInterPro annotationAdd BLAST93

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033912
KOiK01756
OMAiASSCEKI
OrthoDBiPOG091H0168

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR019468 AdenyloSucc_lyase_C
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
PfamiView protein in Pfam
PF10397 ADSL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SMARTiView protein in SMART
SM00998 ADSL_C, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A7H1B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVERYSREIM AKKWDMQAKY DAWLKVELAA VKAWNKLGLI NDTDCEKILK
60 70 80 90 100
NAKFDIARID EIEKTTKHDV IAFLTSVSES LGEESRFVHY AMTSSDCIDT
110 120 130 140 150
AVALQIKESL ELILEDVSLL LEAIKKRALE HKNTLMVGRS HGIHGEPITF
160 170 180 190 200
GLVLAIWYDE ISHAKELLEH AKEVISYGKI SGAMGNFAHA PLEFEEEVCK
210 220 230 240 250
NLGLKAAPVS NQVIQRDRYA QVISAIAILA SSCEQIAVAI RHFQRTEVYE
260 270 280 290 300
AEEYFSVGQK GSSAMPHKRN PVLSENITGL CRVLRSFVTP ALENVALWHE
310 320 330 340 350
RDISHSSVER FILPDAFITA DFMLMRLTNL IDKLLVYPEN MMKNLNLTGG
360 370 380 390 400
LVFSGRVLLE LPFKGISREE AYKIVQRNAM KVWADLQNGK AAINEKNESL
410 420 430 440
FLLALLGDED LRKSLSEEDV RKCFDYNYYT KNVDAIFKRT FK
Length:442
Mass (Da):50,170
Last modified:September 11, 2007 - v1
Checksum:iDF2C5678536B748B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000768 Genomic DNA Translation: ABS43478.1

Genome annotation databases

EnsemblBacteriaiABS43478; ABS43478; JJD26997_0025
KEGGicjd:JJD26997_0025

Similar proteinsi

Entry informationi

Entry nameiA7H1B3_CAMJD
AccessioniPrimary (citable) accession number: A7H1B3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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