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A7H0X7 (UPPP_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Ccur92_18150
ORF Names:CCV52592_0067
OrganismCampylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]
Taxonomic identifier360105 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062791

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7H0X7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 6C3F11303F9D5EDB

FASTA26428,688
        10         20         30         40         50         60 
MDIVHIIVLS LVQGITEFLP ISSSAHLVLV PKLLGWPDQG LAFDVAVHIG TLTAIVFYFK 

        70         80         90        100        110        120 
DSIFGLLRDF FVSIVRRERV GDSTLVWAVC FATIPAGIFG LAFNSLIEEY TRSGIVIAVT 

       130        140        150        160        170        180 
TIIFGVVLYL ADKRVGTKSE YDVTIKLALI IGLAQALALI PGVSRSGITM SAALFLGFSR 

       190        200        210        220        230        240 
VGSANFSFLM SIPIILLAGG LESVKLIRHD ISYVWSDLAL AALISAVSAY ICVKLFMSII 

       250        260 
SKMSMTPFVV YRLILGVFLL FIFV 

« Hide

References

[1]"Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 525.92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000767 Genomic DNA. Translation: EAU00352.1.
RefSeqYP_001409119.1. NC_009715.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360105.CCV52592_0067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAU00352; EAU00352; CCV52592_0067.
GeneID5406455.
KEGGccv:CCV52592_0067.
PATRIC20034267. VBICamCur47627_1912.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAIEGPFRD.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCCUR360105:GJ9P-1998-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CAMC5
AccessionPrimary (citable) accession number: A7H0X7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families