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A7H0X7

- UPPP_CAMC5

UniProt

A7H0X7 - UPPP_CAMC5

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-1998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Ccur92_18150
ORF Names:CCV52592_0067
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5921HelicalUniRule annotationAdd
BLAST
Transmembranei83 – 10321HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei181 – 20121HelicalUniRule annotationAdd
BLAST
Transmembranei220 – 24021HelicalUniRule annotationAdd
BLAST
Transmembranei244 – 26421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Undecaprenyl-diphosphatasePRO_1000062791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0067.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

A7H0X7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIVHIIVLS LVQGITEFLP ISSSAHLVLV PKLLGWPDQG LAFDVAVHIG
60 70 80 90 100
TLTAIVFYFK DSIFGLLRDF FVSIVRRERV GDSTLVWAVC FATIPAGIFG
110 120 130 140 150
LAFNSLIEEY TRSGIVIAVT TIIFGVVLYL ADKRVGTKSE YDVTIKLALI
160 170 180 190 200
IGLAQALALI PGVSRSGITM SAALFLGFSR VGSANFSFLM SIPIILLAGG
210 220 230 240 250
LESVKLIRHD ISYVWSDLAL AALISAVSAY ICVKLFMSII SKMSMTPFVV
260
YRLILGVFLL FIFV
Length:264
Mass (Da):28,688
Last modified:September 11, 2007 - v1
Checksum:i6C3F11303F9D5EDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA. Translation: EAU00352.1.
RefSeqiYP_001409119.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAU00352; EAU00352; CCV52592_0067.
GeneIDi5406455.
KEGGiccv:CCV52592_0067.
PATRICi20034267. VBICamCur47627_1912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA. Translation: EAU00352.1 .
RefSeqi YP_001409119.1. NC_009715.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAU00352 ; EAU00352 ; CCV52592_0067 .
GeneIDi 5406455.
KEGGi ccv:CCV52592_0067.
PATRICi 20034267. VBICamCur47627_1912.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CCUR360105:GJ9P-1998-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiUPPP_CAMC5
AccessioniPrimary (citable) accession number: A7H0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3