A7H0X7 (UPPP_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Ccur92_18150
ORF Names:	CCV52592_0067

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter curvus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000062791
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A7H0X7 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 6C3F11303F9D5EDB	FASTA	264	28,688
	10 20 30 40 50 60 MDIVHIIVLS LVQGITEFLP ISSSAHLVLV PKLLGWPDQG LAFDVAVHIG TLTAIVFYFK 70 80 90 100 110 120 DSIFGLLRDF FVSIVRRERV GDSTLVWAVC FATIPAGIFG LAFNSLIEEY TRSGIVIAVT 130 140 150 160 170 180 TIIFGVVLYL ADKRVGTKSE YDVTIKLALI IGLAQALALI PGVSRSGITM SAALFLGFSR 190 200 210 220 230 240 VGSANFSFLM SIPIILLAGG LESVKLIRHD ISYVWSDLAL AALISAVSAY ICVKLFMSII 250 260 SKMSMTPFVV YRLILGVFLL FIFV

References

[1]

"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 525.92.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000767 Genomic DNA. Translation: EAU00352.1.
RefSeq	YP_001409119.1. NC_009715.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	360105.CCV52592_0067.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EAU00352; EAU00352; CCV52592_0067.
GeneID	5406455.
KEGG	ccv:CCV52592_0067.
PATRIC	20034267. VBICamCur47627_1912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	SAYICVK.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	CCUR360105:GJ9P-1998-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CAMC5

Accession

Primary (citable) accession number: A7H0X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program