A7H099 (A7H099_CAMC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL EAU01047.1
EC=2.4.1.182 EMBL EAU01047.1

Gene names

Name:	lpxB EMBL EAU01047.1
Ordered Locus Names:	Ccur92_15870
ORF Names:	CCV52592_1652 EMBL EAU01047.1

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL EAU01047.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7H099 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 21A52DD17A9544FF	FASTA	347	39,131
	10 20 30 40 50 60 MRKILVCALE PSANLHLKEI LANFDEPYEL VGIFSENLGS PYMKSSEFSA MGFVEILPLI 70 80 90 100 110 120 FKAKRAMKQM KEFAKEVDAV LLIDSPAFNL PLARAIKEVC IKTPITYYIL PQVWAWKPKR 130 140 150 160 170 180 VAVVQRYCDH LASILPFDAK FYDRATYVGH PLLDEIKVRK TALERSGKVA FLPGSRKSEI 190 200 210 220 230 240 MRLMPIYKEL ARDIDAKKLL VVPPFLLGKI DELYGDVSEF EVVSDTPSAL IESDFAFICS 250 260 270 280 290 300 GTATLEAALI GTPFVLAYKA KAIDVFIARR FVKVKHAGLA NIMFDFMQKP ALHEEFIQED 310 320 330 340 ATARNLLSAY ERCDRAKFLI GCEELRAYLG HGSAKNVVKI LKNQNLE

References

[1]	"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000767 Genomic DNA. Translation: EAU01047.1.
RefSeq	YP_001408891.1. NC_009715.1.
3D structure databases
ProteinModelPortal	A7H099.
ModBase	Search...
Protein-protein interaction databases
STRING	A7H099.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5407471.
GenomeReviews	Gene locus Ccur92_15870 in contig CP000767_GR.
KEGG	ccv:CCV52592_1652.
PATRIC	20033775. VBICamCur47627_1672.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	HEEFIQE.
ProtClustDB	PRK14089.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7H099_CAMC5

Accession

Primary (citable) accession number: A7H099

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)