ID   FTHS_CAMC5              Reviewed;         550 AA.
AC   A7GZZ0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543};
GN   OrderedLocusNames=Ccur92_14780; ORFNames=CCV52592_0358;
OS   Campylobacter curvus (strain 525.92).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360105;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=525.92;
RA   Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA   Mandrell R.E., Lastovica A.J., Nelson K.E.;
RT   "Genome sequence of Campylobacter curvus 525.92 isolated from human
RT   feces.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3; Evidence={ECO:0000255|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
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DR   EMBL; CP000767; EAT99584.1; -; Genomic_DNA.
DR   RefSeq; WP_011992625.1; NC_009715.2.
DR   AlphaFoldDB; A7GZZ0; -.
DR   SMR; A7GZZ0; -.
DR   STRING; 360105.CCV52592_0358; -.
DR   KEGG; ccv:CCV52592_0358; -.
DR   HOGENOM; CLU_003601_3_3_7; -.
DR   OrthoDB; 9761733at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000006380; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..550
FT                   /note="Formate--tetrahydrofolate ligase"
FT                   /id="PRO_1000068789"
FT   BINDING         60..67
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   550 AA;  59241 MW;  C88B170DDC4A8D78 CRC64;
     MLSDIEITHL AKLDHISKIG AKLGLGEDDM ELYGKFKAKI EPRLDGSNSK LILVTATSPT
     PFGEGKTTMS IGLADALNRL VKKVCLALRE PSLGPVFGIK GGAAGGGYSQ LAPMEDLNLH
     FTGDFHAITS ANNLISAMID NSLYQENPLN IDKILWKRCM DMNDRALRFI TVGQGGKADG
     VEREDGFNIT AASEIMAILC LATSLADLKE RIANIMVAYN DRGEPIYVRD LGCEDAVCIL
     LKDAMKPNLF QTIEHTPTLV HGGPFANIAH GCNSIIATKT ALNLADFVIT EAGFGSELGA
     EKFIDIKCRV AGIAPDAVVL VSTIRSLKYN GGADKESITK PNMSALEVGI ANLGGHIENL
     KQKFGLNVVV ALNKFGFDED SEIDFVRDYC AKFGVKMAVC ENFVKGGEGA LELANFVLEE
     LKKPNDMKFA YETSDDTKSK ITKIATEIYG AGEVVFEEAA QKALEKIKKL GLEKLPVCIA
     KTQYSFSDDA KLLGRAKGFK FSVKDLQIRT GAGFIVAVCG KIMLMPGLPK TPSALNMHID
     TKTGEISGLA
//