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A7GZZ0

- FTHS_CAMC5

UniProt

A7GZZ0 - FTHS_CAMC5

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Ccur92_14780, CCV52592_0358
Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 678ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-1627-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Ccur92_14780
ORF Names:CCV52592_0358
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000068789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0358.

Structurei

3D structure databases

ProteinModelPortaliA7GZZ0.
SMRiA7GZZ0. Positions 4-548.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GZZ0-1 [UniParc]FASTAAdd to Basket

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MLSDIEITHL AKLDHISKIG AKLGLGEDDM ELYGKFKAKI EPRLDGSNSK    50
LILVTATSPT PFGEGKTTMS IGLADALNRL VKKVCLALRE PSLGPVFGIK 100
GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLN 150
IDKILWKRCM DMNDRALRFI TVGQGGKADG VEREDGFNIT AASEIMAILC 200
LATSLADLKE RIANIMVAYN DRGEPIYVRD LGCEDAVCIL LKDAMKPNLF 250
QTIEHTPTLV HGGPFANIAH GCNSIIATKT ALNLADFVIT EAGFGSELGA 300
EKFIDIKCRV AGIAPDAVVL VSTIRSLKYN GGADKESITK PNMSALEVGI 350
ANLGGHIENL KQKFGLNVVV ALNKFGFDED SEIDFVRDYC AKFGVKMAVC 400
ENFVKGGEGA LELANFVLEE LKKPNDMKFA YETSDDTKSK ITKIATEIYG 450
AGEVVFEEAA QKALEKIKKL GLEKLPVCIA KTQYSFSDDA KLLGRAKGFK 500
FSVKDLQIRT GAGFIVAVCG KIMLMPGLPK TPSALNMHID TKTGEISGLA 550
Length:550
Mass (Da):59,241
Last modified:September 11, 2007 - v1
Checksum:iC88B170DDC4A8D78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99584.1.
RefSeqiYP_001408782.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAT99584; EAT99584; CCV52592_0358.
GeneIDi5406415.
KEGGiccv:CCV52592_0358.
PATRICi20033542. VBICamCur47627_1556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99584.1 .
RefSeqi YP_001408782.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GZZ0.
SMRi A7GZZ0. Positions 4-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99584 ; EAT99584 ; CCV52592_0358 .
GeneIDi 5406415.
KEGGi ccv:CCV52592_0358.
PATRICi 20033542. VBICamCur47627_1556.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CCUR360105:GJ9P-1627-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiFTHS_CAMC5
AccessioniPrimary (citable) accession number: A7GZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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