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A7GZZ0 (FTHS_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Ccur92_14780
ORF Names:CCV52592_0358
OrganismCampylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]
Taxonomic identifier360105 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068789

Regions

Nucleotide binding60 – 678ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7GZZ0 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C88B170DDC4A8D78

FASTA55059,241
        10         20         30         40         50         60 
MLSDIEITHL AKLDHISKIG AKLGLGEDDM ELYGKFKAKI EPRLDGSNSK LILVTATSPT 

        70         80         90        100        110        120 
PFGEGKTTMS IGLADALNRL VKKVCLALRE PSLGPVFGIK GGAAGGGYSQ LAPMEDLNLH 

       130        140        150        160        170        180 
FTGDFHAITS ANNLISAMID NSLYQENPLN IDKILWKRCM DMNDRALRFI TVGQGGKADG 

       190        200        210        220        230        240 
VEREDGFNIT AASEIMAILC LATSLADLKE RIANIMVAYN DRGEPIYVRD LGCEDAVCIL 

       250        260        270        280        290        300 
LKDAMKPNLF QTIEHTPTLV HGGPFANIAH GCNSIIATKT ALNLADFVIT EAGFGSELGA 

       310        320        330        340        350        360 
EKFIDIKCRV AGIAPDAVVL VSTIRSLKYN GGADKESITK PNMSALEVGI ANLGGHIENL 

       370        380        390        400        410        420 
KQKFGLNVVV ALNKFGFDED SEIDFVRDYC AKFGVKMAVC ENFVKGGEGA LELANFVLEE 

       430        440        450        460        470        480 
LKKPNDMKFA YETSDDTKSK ITKIATEIYG AGEVVFEEAA QKALEKIKKL GLEKLPVCIA 

       490        500        510        520        530        540 
KTQYSFSDDA KLLGRAKGFK FSVKDLQIRT GAGFIVAVCG KIMLMPGLPK TPSALNMHID 

       550 
TKTGEISGLA 

« Hide

References

[1]"Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 525.92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000767 Genomic DNA. Translation: EAT99584.1.
RefSeqYP_001408782.1. NC_009715.1.

3D structure databases

ProteinModelPortalA7GZZ0.
SMRA7GZZ0. Positions 4-548.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360105.CCV52592_0358.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAT99584; EAT99584; CCV52592_0358.
GeneID5406415.
KEGGccv:CCV52592_0358.
PATRIC20033542. VBICamCur47627_1556.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycCCUR360105:GJ9P-1627-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CAMC5
AccessionPrimary (citable) accession number: A7GZZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways