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A7GZZ0

- FTHS_CAMC5

UniProt

A7GZZ0 - FTHS_CAMC5

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi60 – 678ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-1627-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Ccur92_14780
ORF Names:CCV52592_0358
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Formate--tetrahydrofolate ligasePRO_1000068789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0358.

Structurei

3D structure databases

ProteinModelPortaliA7GZZ0.
SMRiA7GZZ0. Positions 4-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GZZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEITHL AKLDHISKIG AKLGLGEDDM ELYGKFKAKI EPRLDGSNSK
60 70 80 90 100
LILVTATSPT PFGEGKTTMS IGLADALNRL VKKVCLALRE PSLGPVFGIK
110 120 130 140 150
GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLN
160 170 180 190 200
IDKILWKRCM DMNDRALRFI TVGQGGKADG VEREDGFNIT AASEIMAILC
210 220 230 240 250
LATSLADLKE RIANIMVAYN DRGEPIYVRD LGCEDAVCIL LKDAMKPNLF
260 270 280 290 300
QTIEHTPTLV HGGPFANIAH GCNSIIATKT ALNLADFVIT EAGFGSELGA
310 320 330 340 350
EKFIDIKCRV AGIAPDAVVL VSTIRSLKYN GGADKESITK PNMSALEVGI
360 370 380 390 400
ANLGGHIENL KQKFGLNVVV ALNKFGFDED SEIDFVRDYC AKFGVKMAVC
410 420 430 440 450
ENFVKGGEGA LELANFVLEE LKKPNDMKFA YETSDDTKSK ITKIATEIYG
460 470 480 490 500
AGEVVFEEAA QKALEKIKKL GLEKLPVCIA KTQYSFSDDA KLLGRAKGFK
510 520 530 540 550
FSVKDLQIRT GAGFIVAVCG KIMLMPGLPK TPSALNMHID TKTGEISGLA
Length:550
Mass (Da):59,241
Last modified:September 11, 2007 - v1
Checksum:iC88B170DDC4A8D78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99584.1.
RefSeqiYP_001408782.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAT99584; EAT99584; CCV52592_0358.
GeneIDi5406415.
KEGGiccv:CCV52592_0358.
PATRICi20033542. VBICamCur47627_1556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99584.1 .
RefSeqi YP_001408782.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GZZ0.
SMRi A7GZZ0. Positions 4-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99584 ; EAT99584 ; CCV52592_0358 .
GeneIDi 5406415.
KEGGi ccv:CCV52592_0358.
PATRICi 20033542. VBICamCur47627_1556.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CCUR360105:GJ9P-1627-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiFTHS_CAMC5
AccessioniPrimary (citable) accession number: A7GZZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3