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A7GZZ0

- FTHS_CAMC5

UniProt

A7GZZ0 - FTHS_CAMC5

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi60 – 678ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCUR360105:GJ9P-1627-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ccur92_14780
    ORF Names:CCV52592_0358
    OrganismiCampylobacter curvus (strain 525.92)
    Taxonomic identifieri360105 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000006380: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Formate--tetrahydrofolate ligasePRO_1000068789Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360105.CCV52592_0358.

    Structurei

    3D structure databases

    ProteinModelPortaliA7GZZ0.
    SMRiA7GZZ0. Positions 4-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7GZZ0-1 [UniParc]FASTAAdd to Basket

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    MLSDIEITHL AKLDHISKIG AKLGLGEDDM ELYGKFKAKI EPRLDGSNSK    50
    LILVTATSPT PFGEGKTTMS IGLADALNRL VKKVCLALRE PSLGPVFGIK 100
    GGAAGGGYSQ LAPMEDLNLH FTGDFHAITS ANNLISAMID NSLYQENPLN 150
    IDKILWKRCM DMNDRALRFI TVGQGGKADG VEREDGFNIT AASEIMAILC 200
    LATSLADLKE RIANIMVAYN DRGEPIYVRD LGCEDAVCIL LKDAMKPNLF 250
    QTIEHTPTLV HGGPFANIAH GCNSIIATKT ALNLADFVIT EAGFGSELGA 300
    EKFIDIKCRV AGIAPDAVVL VSTIRSLKYN GGADKESITK PNMSALEVGI 350
    ANLGGHIENL KQKFGLNVVV ALNKFGFDED SEIDFVRDYC AKFGVKMAVC 400
    ENFVKGGEGA LELANFVLEE LKKPNDMKFA YETSDDTKSK ITKIATEIYG 450
    AGEVVFEEAA QKALEKIKKL GLEKLPVCIA KTQYSFSDDA KLLGRAKGFK 500
    FSVKDLQIRT GAGFIVAVCG KIMLMPGLPK TPSALNMHID TKTGEISGLA 550
    Length:550
    Mass (Da):59,241
    Last modified:September 11, 2007 - v1
    Checksum:iC88B170DDC4A8D78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000767 Genomic DNA. Translation: EAT99584.1.
    RefSeqiYP_001408782.1. NC_009715.1.

    Genome annotation databases

    EnsemblBacteriaiEAT99584; EAT99584; CCV52592_0358.
    GeneIDi5406415.
    KEGGiccv:CCV52592_0358.
    PATRICi20033542. VBICamCur47627_1556.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000767 Genomic DNA. Translation: EAT99584.1 .
    RefSeqi YP_001408782.1. NC_009715.1.

    3D structure databases

    ProteinModelPortali A7GZZ0.
    SMRi A7GZZ0. Positions 4-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360105.CCV52592_0358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAT99584 ; EAT99584 ; CCV52592_0358 .
    GeneIDi 5406415.
    KEGGi ccv:CCV52592_0358.
    PATRICi 20033542. VBICamCur47627_1556.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CCUR360105:GJ9P-1627-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 525.92.

    Entry informationi

    Entry nameiFTHS_CAMC5
    AccessioniPrimary (citable) accession number: A7GZZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3