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A7GZU8 (DCUP_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:Ccur92_14360
ORF Names:CCV52592_1470
OrganismCampylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]
Taxonomic identifier360105 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023888

Regions

Region21 – 255Substrate binding By similarity

Sites

Binding site711Substrate By similarity
Binding site1481Substrate By similarity
Binding site2031Substrate By similarity
Binding site3161Substrate By similarity
Site711Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A7GZU8 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: D0235D20DE425021

FASTA34238,027
        10         20         30         40         50         60 
MIFVDACLKK PTPYTPVWMM RQAGRYLPEY MAVRERAGDF LSLCKDYKKA SAVTIQPVEI 

        70         80         90        100        110        120 
LGVDAAILFS DILVVPLEMG MGLRFEKGEG PVFDRPVKTA GDLAVLDVDR AVKNLSYVYD 

       130        140        150        160        170        180 
TIALTRENLA RDKALIGFCG APWTIATYMI EGGGTKTYAV CKKLLYTNPE FLHQILAKVT 

       190        200        210        220        230        240 
AALTDYVKAQ IRAGVDAVQI FDSWAGALEE SAYFEFGWRY ILQIVDSVKT EFPDIPLIVF 

       250        260        270        280        290        300 
PKGVSGFLDK ISGNFEVFGV DWSTPIGLAK EKLSPKFVLQ GNMEPTRLYS KKAIDAGVDK 

       310        320        330        340 
ILNTMKGAPH IFNLGHGILP DIPVENAKYF IKQVQEKSHN HK

« Hide

References

[1]"Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 525.92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000767 Genomic DNA. Translation: EAT99979.1.
RefSeqYP_001408740.1. NC_009715.1.

3D structure databases

ProteinModelPortalA7GZU8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GZU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5407566.
GenomeReviewsGene locus Ccur92_14360 in contig CP000767_GR.
KEGGccv:CCV52592_1470.
PATRIC20033458. VBICamCur47627_1514.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycCCUR360105:CCV52592_1470-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CAMC5
AccessionPrimary (citable) accession number: A7GZU8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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