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A7GZP5

- NAPA_CAMC5

UniProt

A7GZP5 - NAPA_CAMC5

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Protein
Periplasmic nitrate reductase
Gene
napA, Ccur92_13830, CCV52592_1928
Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism By similarity.UniRule annotation

Catalytic activityi

Nitrite + acceptor = nitrate + reduced acceptor.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster By similarity.UniRule annotation
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Iron-sulfur (4Fe-4S) By similarity
Metal bindingi47 – 471Iron-sulfur (4Fe-4S) By similarity
Metal bindingi51 – 511Iron-sulfur (4Fe-4S) By similarity
Metal bindingi79 – 791Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. electron carrier activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. molybdenum ion binding Source: InterPro
  5. nitrate reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
  2. nitrate assimilation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Nitrate assimilation, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-1525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic nitrate reductase (EC:1.7.99.4)
Gene namesi
Name:napA
Ordered Locus Names:Ccur92_13830
ORF Names:CCV52592_1928
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Periplasm By similarity UniRule annotation

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Tat-type signal Reviewed prediction
Add
BLAST
Chaini31 – 926896Periplasmic nitrate reductaseUniRule annotation
PRO_1000069711Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.UniRule annotation

Interactioni

Subunit structurei

Interacts with NapB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360105.CCV52592_1928.

Structurei

3D structure databases

ProteinModelPortaliA7GZP5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 93574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0243.
HOGENOMiHOG000031441.
KOiK02567.
OMAiFNQHQRG.
OrthoDBiEOG6CVV7G.

Family and domain databases

HAMAPiMF_01630. Nitrate_reduct.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view]
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR01706. NAPA. 1 hit.
PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7GZP5-1 [UniParc]FASTAAdd to Basket

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MNRRDFIKSA AASAACASAG IAIPANLSAA SEAEKGWRWD KAACRFCGTG    50
CGIMVATKEG KIVAVKGDPE APVNRGLNCI KGYFNAKIMY GEDRITHPLL 100
RVNEKGEFDK KGKFKQVSWK QAFDVMEAQF RKTYDELGPH GVGVLGSGQY 150
TIPEGYTAAK MMKAGFRSNS IDPNARHCMA SAVVGFIQVF GIDEPSGCFD 200
DIELTDTIVA WGANMAEMHP ILWARVSDRK LSNPDRVKVV NLSTYSTRTS 250
NLADIEIIFA PSADLAIWNY IAREIVYNHP EMIDEEFVKK HCIFTTGPAD 300
IGYGLRPDIK YKKYLSSELD TAATEKSKVL SEAEGVTLSY LGLKAGDTME 350
NKNTATAGNH WHISFEEFKK ALAPYTLEFT AKVAKGDPNE DIEEFKGKLK 400
ALADLYIEKN RKVVSFWTMG FNQHQRGTWV NEQAYMVHFL LGKQALPGSG 450
AFSLTGQPSA CGTAREVGTF VHRLPADMVV NNPKHREISE KIWKLPAGTL 500
NGIPGSHYVK MMRDLEDGKV KFIWVQVNNP WQNTANANHW IKAAREMDNF 550
IVVSDPYPGI SAKVADLILP TAMIYEKWGA YGNAERRTQH WRQQVLPVGE 600
AMPDIWQMLE FSKRFKLKDV WGEKKLNDKV TLPSVLDAAK AMGYSEEDTL 650
FDVLFANEEA KSYPANDPIM ENFDNTEVFG DKRGVIGSDG KEFKGYGFFV 700
HKYLWEEYRK FGLGHGHDLA DFDTYHRVRG LRWPVVDGKE TQWRFNTKFD 750
PYAKKAAPND KFAFYGNKAA ALPSGDLKGV TDKEKTPLTN KAKIFFRPYM 800
DPCEMPSSEY PFWLCTGRVL EHWHSGTMTM RVPELYRAVP EALCYMHEQD 850
AAKLGVLQNE IVWIESRRGK VKARVDLKGR NKPPVGLVYV PWFDENVFIN 900
KVTLDSTCPI SKETDYKKCA VKIYKA 926
Length:926
Mass (Da):104,203
Last modified:September 11, 2007 - v1
Checksum:iA5B0043D6D56F8B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99733.1.
RefSeqiYP_001408687.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAT99733; EAT99733; CCV52592_1928.
GeneIDi5407339.
KEGGiccv:CCV52592_1928.
PATRICi20033344. VBICamCur47627_1458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99733.1 .
RefSeqi YP_001408687.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GZP5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_1928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99733 ; EAT99733 ; CCV52592_1928 .
GeneIDi 5407339.
KEGGi ccv:CCV52592_1928.
PATRICi 20033344. VBICamCur47627_1458.

Phylogenomic databases

eggNOGi COG0243.
HOGENOMi HOG000031441.
KOi K02567.
OMAi FNQHQRG.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci CCUR360105:GJ9P-1525-MONOMER.

Family and domain databases

HAMAPi MF_01630. Nitrate_reduct.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR010051. Periplasm_NO3_reductase_lsu.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
[Graphical view ]
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR01706. NAPA. 1 hit.
PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiNAPA_CAMC5
AccessioniPrimary (citable) accession number: A7GZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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