A7GZM8 (ALR_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Ccur92_13660
ORF Names:	CCV52592_1338

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Alanine racemase HAMAP MF_01201		PRO_1000138585
Sites
	Active site	33	1	Proton acceptor; specific for D-alanine By similarity
	Active site	246	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	33	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GZM8 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: FA5A43D6E5CE3540	FASTA	337	37,868
	10 20 30 40 50 60 MSEIRLNKKA YIHNLMQISN KAGGKERVML VLKDNAYGHG AKLIAAAASE FGIKFCAVKS 70 80 90 100 110 120 QSEALEIQRN FEKILILSHI ANGDEDQNFI YAINDMKGLN RIKRGTRIHL VIDTNMHRNG 130 140 150 160 170 180 LKFSELEAAF GPIKERGLAL EGAYTHFRAS DEMNADYFVQ RQNFKEAKAE ILRLCEKFAM 190 200 210 220 230 240 PHPIFHSHNS AALERFGEFD DDMVRVGIAQ HGYAQFDDSL NLKPVLSLWA QKVSERVLKA 250 260 270 280 290 300 GQCVGYGAKF CADKDINIAT YDLGYGDGLL RYAGDGELPL ANGKAMLGKM SMDSFSCEDA 310 320 330 GEWVCVFDDA NVWARYFDTI NYDILVKLSP NIKRKFV

References

[1]

"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 525.92.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000767 Genomic DNA. Translation: EAT99457.1.
RefSeq	YP_001408670.1. NC_009715.1.
3D structure databases
ProteinModelPortal	A7GZM8.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GZM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5407667.
GenomeReviews	Gene locus Ccur92_13660 in contig CP000767_GR.
KEGG	ccv:CCV52592_1338.
PATRIC	20033310. VBICamCur47627_1441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
HOGENOM	HBG321354.
OMA	FKADKDM.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	CCUR360105:CCV52592_1338-MONOMER.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_CAMC5

Accession

Primary (citable) accession number: A7GZM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program