Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A7GZ81

- SYL_CAMC5

UniProt

A7GZ81 - SYL_CAMC5

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei592 – 5921ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCUR360105:GJ9P-1325-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Ccur92_12190
    ORF Names:CCV52592_0710
    OrganismiCampylobacter curvus (strain 525.92)
    Taxonomic identifieri360105 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000006380: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Leucine--tRNA ligasePRO_0000334739Add
    BLAST

    Proteomic databases

    PRIDEiA7GZ81.

    Interactioni

    Protein-protein interaction databases

    STRINGi360105.CCV52592_0710.

    Structurei

    3D structure databases

    ProteinModelPortaliA7GZ81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5411"HIGH" regionAdd
    BLAST
    Motifi589 – 5935"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7GZ81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQNSKYEAA KIEKKWQEIW HKNGEFEPKD DYTLPKKYIL SMFPYPSGRI    50
    HMGHVRNYSI GDALARYYRK NCFNVLHPIG FDSFGMPAEN AAIKHKIHPK 100
    KWTYENIDYM KKELSSLGFS FSDRRMLATS DPLYTKWEQS FFIKMFEKGL 150
    VYRKSAIVNW CEHDQTVLAN EQVEDGCCWR CGNEVVQREF PGYYFKITQY 200
    AEELLNDLKT LEGKWPNQVI AMQENWIGKS SGLEFKFYLD DASSRALGGK 250
    FDGFEVFTTR PDTIYGVSYV ALAPEHKVVR ALLSSEILDD TKKAKIKSIL 300
    NQSPRERQAS DKDGVFLDIY MLHPLTNEPV PVWVANFILA DYGSGAIMAV 350
    PAHDQRDYEF ASKFGLPIKQ VVMPKEGKFD TSKANAEYGI SINSPLINGL 400
    ETKQAKQAII EKFEKDGLGK RITNYKLRDW GISRQRYWGA PIPIVHCPNC 450
    GVVPENEQNL PIALPDDVVI TGEGNPLDKH PTWKYTKCPK CGHDAVRETD 500
    TMDTFVESSW YFARFASDEK TWQQTAFDKK SVDYWMSVDQ YIGGIEHAIL 550
    HLLYARFFQK VLRDLGYLRD DEPFSNLLTQ GMVLKDGKKM SKSKGNVVDP 600
    DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAYRFL NRLWDKAKTI 650
    KKSEILPAIE HANLNKDEKY ARMKVYEALK KSNEVFNETF AFNTLIAACM 700
    EALNALNAQD NDDVNTEGFF IILNLLEPIV PHIANELSEE LFRRKNFTKL 750
    EILEEVFVKD TINLAVTVNG KKRAEFEISA DASEADVLQT AKASVAKWIE 800
    GKEIIKEIYI KGKLVNLVVK G 821
    Length:821
    Mass (Da):93,990
    Last modified:September 11, 2007 - v1
    Checksum:i66AF609B342A47A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000767 Genomic DNA. Translation: EAU00405.1.
    RefSeqiYP_001408523.1. NC_009715.1.

    Genome annotation databases

    EnsemblBacteriaiEAU00405; EAU00405; CCV52592_0710.
    GeneIDi5406901.
    KEGGiccv:CCV52592_0710.
    PATRICi20032954. VBICamCur47627_1284.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000767 Genomic DNA. Translation: EAU00405.1 .
    RefSeqi YP_001408523.1. NC_009715.1.

    3D structure databases

    ProteinModelPortali A7GZ81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360105.CCV52592_0710.

    Proteomic databases

    PRIDEi A7GZ81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAU00405 ; EAU00405 ; CCV52592_0710 .
    GeneIDi 5406901.
    KEGGi ccv:CCV52592_0710.
    PATRICi 20032954. VBICamCur47627_1284.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CCUR360105:GJ9P-1325-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 525.92.

    Entry informationi

    Entry nameiSYL_CAMC5
    AccessioniPrimary (citable) accession number: A7GZ81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3