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A7GZ81

- SYL_CAMC5

UniProt

A7GZ81 - SYL_CAMC5

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei592 – 5921ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-1325-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Ccur92_12190
ORF Names:CCV52592_0710
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Leucine--tRNA ligasePRO_0000334739Add
BLAST

Proteomic databases

PRIDEiA7GZ81.

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0710.

Structurei

3D structure databases

ProteinModelPortaliA7GZ81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionAdd
BLAST
Motifi589 – 5935"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GZ81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQNSKYEAA KIEKKWQEIW HKNGEFEPKD DYTLPKKYIL SMFPYPSGRI
60 70 80 90 100
HMGHVRNYSI GDALARYYRK NCFNVLHPIG FDSFGMPAEN AAIKHKIHPK
110 120 130 140 150
KWTYENIDYM KKELSSLGFS FSDRRMLATS DPLYTKWEQS FFIKMFEKGL
160 170 180 190 200
VYRKSAIVNW CEHDQTVLAN EQVEDGCCWR CGNEVVQREF PGYYFKITQY
210 220 230 240 250
AEELLNDLKT LEGKWPNQVI AMQENWIGKS SGLEFKFYLD DASSRALGGK
260 270 280 290 300
FDGFEVFTTR PDTIYGVSYV ALAPEHKVVR ALLSSEILDD TKKAKIKSIL
310 320 330 340 350
NQSPRERQAS DKDGVFLDIY MLHPLTNEPV PVWVANFILA DYGSGAIMAV
360 370 380 390 400
PAHDQRDYEF ASKFGLPIKQ VVMPKEGKFD TSKANAEYGI SINSPLINGL
410 420 430 440 450
ETKQAKQAII EKFEKDGLGK RITNYKLRDW GISRQRYWGA PIPIVHCPNC
460 470 480 490 500
GVVPENEQNL PIALPDDVVI TGEGNPLDKH PTWKYTKCPK CGHDAVRETD
510 520 530 540 550
TMDTFVESSW YFARFASDEK TWQQTAFDKK SVDYWMSVDQ YIGGIEHAIL
560 570 580 590 600
HLLYARFFQK VLRDLGYLRD DEPFSNLLTQ GMVLKDGKKM SKSKGNVVDP
610 620 630 640 650
DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAYRFL NRLWDKAKTI
660 670 680 690 700
KKSEILPAIE HANLNKDEKY ARMKVYEALK KSNEVFNETF AFNTLIAACM
710 720 730 740 750
EALNALNAQD NDDVNTEGFF IILNLLEPIV PHIANELSEE LFRRKNFTKL
760 770 780 790 800
EILEEVFVKD TINLAVTVNG KKRAEFEISA DASEADVLQT AKASVAKWIE
810 820
GKEIIKEIYI KGKLVNLVVK G
Length:821
Mass (Da):93,990
Last modified:September 11, 2007 - v1
Checksum:i66AF609B342A47A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAU00405.1.
RefSeqiWP_011992459.1. NC_009715.1.
YP_001408523.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAU00405; EAU00405; CCV52592_0710.
GeneIDi5406901.
KEGGiccv:CCV52592_0710.
PATRICi20032954. VBICamCur47627_1284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAU00405.1 .
RefSeqi WP_011992459.1. NC_009715.1.
YP_001408523.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GZ81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0710.

Proteomic databases

PRIDEi A7GZ81.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAU00405 ; EAU00405 ; CCV52592_0710 .
GeneIDi 5406901.
KEGGi ccv:CCV52592_0710.
PATRICi 20032954. VBICamCur47627_1284.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CCUR360105:GJ9P-1325-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiSYL_CAMC5
AccessioniPrimary (citable) accession number: A7GZ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3