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A7GZ81 (SYL_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Ccur92_12190
ORF Names:CCV52592_0710
OrganismCampylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]
Taxonomic identifier360105 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length821 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 821821Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334739

Regions

Motif44 – 5411"HIGH" region HAMAP-Rule MF_00049
Motif589 – 5935"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5921ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7GZ81 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 66AF609B342A47A3

FASTA82193,990
        10         20         30         40         50         60 
MAQNSKYEAA KIEKKWQEIW HKNGEFEPKD DYTLPKKYIL SMFPYPSGRI HMGHVRNYSI 

        70         80         90        100        110        120 
GDALARYYRK NCFNVLHPIG FDSFGMPAEN AAIKHKIHPK KWTYENIDYM KKELSSLGFS 

       130        140        150        160        170        180 
FSDRRMLATS DPLYTKWEQS FFIKMFEKGL VYRKSAIVNW CEHDQTVLAN EQVEDGCCWR 

       190        200        210        220        230        240 
CGNEVVQREF PGYYFKITQY AEELLNDLKT LEGKWPNQVI AMQENWIGKS SGLEFKFYLD 

       250        260        270        280        290        300 
DASSRALGGK FDGFEVFTTR PDTIYGVSYV ALAPEHKVVR ALLSSEILDD TKKAKIKSIL 

       310        320        330        340        350        360 
NQSPRERQAS DKDGVFLDIY MLHPLTNEPV PVWVANFILA DYGSGAIMAV PAHDQRDYEF 

       370        380        390        400        410        420 
ASKFGLPIKQ VVMPKEGKFD TSKANAEYGI SINSPLINGL ETKQAKQAII EKFEKDGLGK 

       430        440        450        460        470        480 
RITNYKLRDW GISRQRYWGA PIPIVHCPNC GVVPENEQNL PIALPDDVVI TGEGNPLDKH 

       490        500        510        520        530        540 
PTWKYTKCPK CGHDAVRETD TMDTFVESSW YFARFASDEK TWQQTAFDKK SVDYWMSVDQ 

       550        560        570        580        590        600 
YIGGIEHAIL HLLYARFFQK VLRDLGYLRD DEPFSNLLTQ GMVLKDGKKM SKSKGNVVDP 

       610        620        630        640        650        660 
DDIINRYGAD TARLFILFAA PPQKELEWND SAVEGAYRFL NRLWDKAKTI KKSEILPAIE 

       670        680        690        700        710        720 
HANLNKDEKY ARMKVYEALK KSNEVFNETF AFNTLIAACM EALNALNAQD NDDVNTEGFF 

       730        740        750        760        770        780 
IILNLLEPIV PHIANELSEE LFRRKNFTKL EILEEVFVKD TINLAVTVNG KKRAEFEISA 

       790        800        810        820 
DASEADVLQT AKASVAKWIE GKEIIKEIYI KGKLVNLVVK G 

« Hide

References

[1]"Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 525.92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000767 Genomic DNA. Translation: EAU00405.1.
RefSeqYP_001408523.1. NC_009715.1.

3D structure databases

ProteinModelPortalA7GZ81.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360105.CCV52592_0710.

Proteomic databases

PRIDEA7GZ81.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAU00405; EAU00405; CCV52592_0710.
GeneID5406901.
KEGGccv:CCV52592_0710.
PATRIC20032954. VBICamCur47627_1284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCCUR360105:GJ9P-1325-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_CAMC5
AccessionPrimary (citable) accession number: A7GZ81
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries