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Protein

Thymidylate kinase

Gene

tmk

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Ccur92_09580
ORF Names:CCV52592_1098
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000006380 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001235631 – 194Thymidylate kinaseAdd BLAST194

Proteomic databases

PRIDEiA7GYH0

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_1098

Structurei

3D structure databases

ProteinModelPortaliA7GYH0
SMRiA7GYH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229077
KOiK00943
OMAiKTHAYAL

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

A7GYH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVLFEGVDG VGKSTQIEMI ARAHEDSLVT KEPGGTKIGQ KLREILLGGD
60 70 80 90 100
FKLSARAEIL LFLADRAEHY QKMIKPNSSR LILSDRGFVS GVAYALANDA
110 120 130 140 150
SLKIDDLLWL NSFALEGKFA DKIVFFEASE TLIKKRLSSR GLIDAIEARG
160 170 180 190
LKYLLKVQEC MKEVLKAHKF NVLYIDASED IATINAKIEN FIKF
Length:194
Mass (Da):21,702
Last modified:September 11, 2007 - v1
Checksum:iB9A357C076862C93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA Translation: EAU00131.1
RefSeqiWP_009650446.1, NC_009715.2

Genome annotation databases

EnsemblBacteriaiEAU00131; EAU00131; CCV52592_1098
KEGGiccv:CCV52592_1098

Similar proteinsi

Entry informationi

Entry nameiKTHY_CAMC5
AccessioniPrimary (citable) accession number: A7GYH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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