Reviewed, UniProtKB/Swiss-Prot A7GYE1 (AROB_CAMC5)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Ccur92_09290
ORF Names:	CCV52592_1438

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000117476

Sequences

	Sequence		Length	Mass (Da)
	A7GYE1-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 4A93584DFD13342E	FASTA	346	38,929
	10 20 30 40 50 60 MQIRLNLEQK KYGYNVYINE LERIEIKGKT AIVTNPKIAG LHLNTLLNSL KCDEYFIISV 70 80 90 100 110 120 PDGEEYKNLA TIELILEQLF TSKLDRSSTL IAFGGGVISD MTGFAASIYE RGINFINIPT 130 140 150 160 170 180 TLLAQVDASV GGKTGVNNKF GKNMIGSFYQ PKAVYCESKF LRTLAFREFN AGLAEAVKMA 190 200 210 220 230 240 VTFDKEMFEW LENVTLDEEQ NLAKLVERSV LIKARVVEAD EKERGLRALL NYGHTFAHVI 250 260 270 280 290 300 ENETGYKKYL HGEAVAIGMN MANSLSVKLG LMSEKDALRI KELLAKFSLP THYVLRDESA 310 320 330 340 FYEAFMLDKK TQEGSVKFIL SNGIGSAVMK NDIKRDDVIK ILREFK

References

[1]	"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000767 Genomic DNA. Translation: EAT99536.2.
RefSeq	YP_001408233.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7GYE1.
Genome annotation databases
GeneID	5406474.
GenomeReviews	Gene locus Ccur92_09290 in contig CP000767_GR.
KEGG	ccv:CCV52592_1438.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_CAMC5

Accession

Primary (citable) accession number: A7GYE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)