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Protein

Acetate kinase

Gene

ackA

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Active sitei145Proton donor/acceptorUniRule annotation1
Sitei177Transition state stabilizerUniRule annotation1
Sitei238Transition state stabilizerUniRule annotation1
Metal bindingi380MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 209ATPUniRule annotation5
Nucleotide bindingi279 – 281ATPUniRule annotation3
Nucleotide bindingi326 – 330ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:G1G9H-942-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Ccur92_09160
ORF Names:CCV52592_1158
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000006380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022141 – 398Acetate kinaseAdd BLAST398

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi360105.CCV52592_1158.

Structurei

3D structure databases

ProteinModelPortaliA7GYC8.
SMRiA7GYC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GYC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVLNSGS SSIKFQLFLM EENRSIASGI VEQIGSENSR AVLKANSKEY
60 70 80 90 100
EKKRAIKDHH EGLDVMNELF RESNTLHDLS ELDGIGHRIV HGGESFFSSM
110 120 130 140 150
IVDDSVIAKI EQISPLAPLH NPGHIAGIKN AMQSSGDVPH VVVFDTVFHQ
160 170 180 190 200
TMPEYAYRYA LPYDICKEHH IRKYGFHGTS HRYVCKRAAS LMGMEFQNFN
210 220 230 240 250
AISLHLGNGA SACAVQNGKS IDTSMGLSPL EGLIMGTRSG DMDPAVVVYL
260 270 280 290 300
LNIGVLKWDE IDTFLNKKSG LFGICGSSDM RDVVTRMAND ERAKLAFEMF
310 320 330 340 350
CYRVKKYIGA YYAVLGHVDA LIFTGGIGEN APNTRQKICD DLKHLGIHVN
360 370 380 390
HDLNFSKERG ERCLDDKNAK IKTFVIPTNE ELEIAIETMR VIKERAKI
Length:398
Mass (Da):44,381
Last modified:September 11, 2007 - v1
Checksum:i93422F90EB81278A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA. Translation: EAT99809.1.
RefSeqiWP_011992266.1. NC_009715.2.

Genome annotation databases

EnsemblBacteriaiEAT99809; EAT99809; CCV52592_1158.
KEGGiccv:CCV52592_1158.

Similar proteinsi

Entry informationi

Entry nameiACKA_CAMC5
AccessioniPrimary (citable) accession number: A7GYC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: February 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome