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Protein

D-alanine--D-alanine ligase

Gene

ddlA

Organism
Campylobacter curvus (strain 525.92)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:G1G9H-937-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Name:ddlAImported
ORF Names:CCV52592_1152Imported
OrganismiCampylobacter curvus (strain 525.92)Imported
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000006380 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_1152

Structurei

3D structure databases

ProteinModelPortaliA7GYC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 324ATP-graspInterPro annotationAdd BLAST192

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000102494
KOiK01921
OMAiRCDFFVI

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A7GYC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGVVFGAK SFEHEISIVS AIVLKNVLKQ ELSFIFCDKE RKFYLIEPTD
60 70 80 90 100
MRANFFSSGK YKKCKKLFLM ACGFYTHSLF GVKRLEVDVY INLIHGMDGE
110 120 130 140 150
DGKFASLFDF YGISYIGPRL EASVMSYNKE LTKFLAQKVG VKTLDYEMIT
160 170 180 190 200
YEELPKFALP IILKPARLGS SIGVSVVKDE SEFEYARDVA FEFDKEVLVE
210 220 230 240 250
PFIEGVKEYN LAGCMIDGKM RFSIVEEPKK KEFLDYEQKY MSFSNESKAQ
260 270 280 290 300
EARIDEELRD RLKENFVKIY GFGFEGAIIR CDFFVIEGEV YLNEINPNPG
310 320 330 340
SLANYLFEDF EAMLNALAAS RLPKERKINI DYKFINSITS AKGSGKI
Length:347
Mass (Da):39,781
Last modified:September 11, 2007 - v1
Checksum:iF26A795969764B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA Translation: EAT99804.1
RefSeqiWP_011992262.1, NC_009715.2

Genome annotation databases

EnsemblBacteriaiEAT99804; EAT99804; CCV52592_1152
KEGGiccv:CCV52592_1152

Similar proteinsi

Entry informationi

Entry nameiA7GYC3_CAMC5
AccessioniPrimary (citable) accession number: A7GYC3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health