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A7GYC3

- A7GYC3_CAMC5

UniProt

A7GYC3 - A7GYC3_CAMC5

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Protein
Submitted name:

D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase)

Gene

CCV52592_1152

Organism
Campylobacter curvus (strain 525.92)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-995-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligase (D-alanylalanine synthetase)(D-Ala-D-Ala ligase)Imported (EC:6.3.2.4Imported)
Gene namesi
ORF Names:CCV52592_1152Imported
OrganismiCampylobacter curvus (strain 525.92)Imported
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_1152.

Structurei

3D structure databases

ProteinModelPortaliA7GYC3.
SMRiA7GYC3. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000102494.
KOiK01921.
OMAiHNGLLKN.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GYC3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLGVVFGAK SFEHEISIVS AIVLKNVLKQ ELSFIFCDKE RKFYLIEPTD
60 70 80 90 100
MRANFFSSGK YKKCKKLFLM ACGFYTHSLF GVKRLEVDVY INLIHGMDGE
110 120 130 140 150
DGKFASLFDF YGISYIGPRL EASVMSYNKE LTKFLAQKVG VKTLDYEMIT
160 170 180 190 200
YEELPKFALP IILKPARLGS SIGVSVVKDE SEFEYARDVA FEFDKEVLVE
210 220 230 240 250
PFIEGVKEYN LAGCMIDGKM RFSIVEEPKK KEFLDYEQKY MSFSNESKAQ
260 270 280 290 300
EARIDEELRD RLKENFVKIY GFGFEGAIIR CDFFVIEGEV YLNEINPNPG
310 320 330 340
SLANYLFEDF EAMLNALAAS RLPKERKINI DYKFINSITS AKGSGKI
Length:347
Mass (Da):39,781
Last modified:September 11, 2007 - v1
Checksum:iF26A795969764B80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99804.1.
RefSeqiWP_011992262.1. NC_009715.1.
YP_001408215.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAT99804; EAT99804; CCV52592_1152.
GeneIDi5406834.
KEGGiccv:CCV52592_1152.
PATRICi20032300. VBICamCur47627_0959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAT99804.1 .
RefSeqi WP_011992262.1. NC_009715.1.
YP_001408215.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GYC3.
SMRi A7GYC3. Positions 1-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_1152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAT99804 ; EAT99804 ; CCV52592_1152 .
GeneIDi 5406834.
KEGGi ccv:CCV52592_1152.
PATRICi 20032300. VBICamCur47627_0959.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000102494.
KOi K01921.
OMAi HNGLLKN.
OrthoDBi EOG6ND0KB.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CCUR360105:GJ9P-995-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92Imported.

Entry informationi

Entry nameiA7GYC3_CAMC5
AccessioniPrimary (citable) accession number: A7GYC3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3