A7GXW3 (A7GXW3_CAMC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase HAMAP MF_00193 RuleBase RU003812
EC=6.3.1.5 HAMAP MF_00193 RuleBase RU003812

Gene names

Name:	nadE HAMAP MF_00193 EMBL EAU00241.1
Ordered Locus Names:	Ccur92_07510
ORF Names:	CCV52592_0125 EMBL EAU00241.1

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193 RuleBase RU003812 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193 SAAS SAAS003694 RuleBase RU004252
Sequence similarities	Belongs to the NAD synthetase family. HAMAP MF_00193 RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS003694 HAMAP MF_00193 RuleBase RU003811 NAD HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00193 SAAS SAAS003694 RuleBase RU003811 EMBL EAU00241.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	31 – 38	8	ATP By similarity HAMAP MF_00193
Sites
	Active site	33	1	By similarity HAMAP MF_00193

Sequences

	Sequence		Length	Mass (Da)
	A7GXW3 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 6199E59DD24ECF4B	FASTA	250	27,216
	10 20 30 40 50 60 MKDYESIKKI LVEFLKNYIT KKSKSKNLLI GVSGGIDSAV VATLCAAAMP KNTHALIMPT 70 80 90 100 110 120 NASSTKNIDD ALNLCKKLGL NFKILNIQAI LDAFGDSIGE DIDKLRKGNL SARVRMSLLY 130 140 150 160 170 180 DYSASINALV VGTSNKSELM LGYGTIFGDL ACAINPIGEL YKTEIFEFAK YLGVDENIIN 190 200 210 220 230 240 KAPSADLWDG QSDEADIGYT YETIDEILKG IAGGNLGASV DKFGQDTVDE IVKRVESNKF 250 KRQMPLIAKI

References

[1]	"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000767 Genomic DNA. Translation: EAU00241.1.
RefSeq	YP_001408055.1. NC_009715.1.
3D structure databases
ProteinModelPortal	A7GXW3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GXW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5407713.
GenomeReviews	Gene locus Ccur92_07510 in contig CP000767_GR.
KEGG	ccv:CCV52592_0125.
PATRIC	20031960. VBICamCur47627_0797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0171.
HOGENOM	HBG351567.
OMA	YDISARD.
ProtClustDB	CLSK978749.
Family and domain databases
HAMAP	MF_00193. NadE. [Tree]
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR022926. NH(3)-dep_NAD(+)_synth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01916.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7GXW3_CAMC5

Accession

Primary (citable) accession number: A7GXW3

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)