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A7GX79

- PNP_CAMC5

UniProt

A7GX79 - PNP_CAMC5

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151MagnesiumUniRule annotation
Metal bindingi521 – 5211MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Ccur92_05170
ORF Names:CCV52592_0953
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Polyribonucleotide nucleotidyltransferasePRO_0000329568Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0953.

Structurei

3D structure databases

ProteinModelPortaliA7GX79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64161KHUniRule annotationAdd
BLAST
Domaini675 – 73460S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GX79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYSIEVNNQ VEIFDLNKVA KQAAGAVMLR VKNTVVLATV ARDDVQVEED
60 70 80 90 100
FLPLTVQYIE KAYAAGRIPG GYVKRETKPG DFETLTARII DRSLRPLFPK
110 120 130 140 150
GYAYPTQIVV MVLSADPEVD LQVVGLNAAS VALYLSDIPV NRPVCGVRVG
160 170 180 190 200
YIDDKFVINP SNSELKSSAL DLYVAGTKDE LLMIEMRSIA QQSSQIIPII
210 220 230 240 250
AIDPMMDPSL NDSITQKQDM NEFSEDRIVE AIDFAGKAIL RASNAYEEAF
260 270 280 290 300
KEHKKEDAIL ELKPEIENEN IAIYIDKFYK NDVKNAINQM AKSERASELG
310 320 330 340 350
KIAKQIASDE VAQKEGWEEG VISNVLGKYK KKIVREQIIN EGVRADGRAL
360 370 380 390 400
DEVRPISIET NVLPNAHGSC LFTRGQTQAL VVATLGTDGD AQMYDILTEK
410 420 430 440 450
TALIEKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALAPSIDINS
460 470 480 490 500
PYTIRLVSEI LESNGSSSMA SVCGGALALR AAGVDTQKLV AGVAMGLIFE
510 520 530 540 550
GDKHAVLTDI MGLEDHDGDM DFKVAGSSDG ITALQMDIKL GGISLEVLKE
560 570 580 590 600
ALYQAKRGRE HILNLMHQAD SKIEVNEDVL PKLELFSVDP SKIVDIIGQA
610 620 630 640 650
GKTIKEIIER FEVSIDLDRE KGEVKIAGGA KKNVDAAKDY IISITSKENS
660 670 680 690 700
RGFGKKPHGH DRRDKDRQKP TFNIGDEFDG VVKSVVDFGA FIELKDGVDG
710 720 730
LLHISKIKTP LNVGDRLKVC VSEQKGNKIS LSLVE
Length:735
Mass (Da):80,567
Last modified:September 11, 2007 - v1
Checksum:i9B6E933740BAC0AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA. Translation: EAU00019.1.
RefSeqiWP_011992002.1. NC_009715.1.
YP_001407821.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAU00019; EAU00019; CCV52592_0953.
GeneIDi5407861.
KEGGiccv:CCV52592_0953.
PATRICi20031464. VBICamCur47627_0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000767 Genomic DNA. Translation: EAU00019.1 .
RefSeqi WP_011992002.1. NC_009715.1.
YP_001407821.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GX79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAU00019 ; EAU00019 ; CCV52592_0953 .
GeneIDi 5407861.
KEGGi ccv:CCV52592_0953.
PATRICi 20031464. VBICamCur47627_0551.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CCUR360105:GJ9P-562-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiPNP_CAMC5
AccessioniPrimary (citable) accession number: A7GX79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3