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A7GX79

- PNP_CAMC5

UniProt

A7GX79 - PNP_CAMC5

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Ccur92_05170, CCV52592_0953
Organism
Campylobacter curvus (strain 525.92)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi515 – 5151Magnesium By similarity
Metal bindingi521 – 5211Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCCUR360105:GJ9P-562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Ccur92_05170
ORF Names:CCV52592_0953
OrganismiCampylobacter curvus (strain 525.92)
Taxonomic identifieri360105 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000006380: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329568Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360105.CCV52592_0953.

Structurei

3D structure databases

ProteinModelPortaliA7GX79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 64161KH
Add
BLAST
Domaini675 – 73460S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GX79-1 [UniParc]FASTAAdd to Basket

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MQYSIEVNNQ VEIFDLNKVA KQAAGAVMLR VKNTVVLATV ARDDVQVEED    50
FLPLTVQYIE KAYAAGRIPG GYVKRETKPG DFETLTARII DRSLRPLFPK 100
GYAYPTQIVV MVLSADPEVD LQVVGLNAAS VALYLSDIPV NRPVCGVRVG 150
YIDDKFVINP SNSELKSSAL DLYVAGTKDE LLMIEMRSIA QQSSQIIPII 200
AIDPMMDPSL NDSITQKQDM NEFSEDRIVE AIDFAGKAIL RASNAYEEAF 250
KEHKKEDAIL ELKPEIENEN IAIYIDKFYK NDVKNAINQM AKSERASELG 300
KIAKQIASDE VAQKEGWEEG VISNVLGKYK KKIVREQIIN EGVRADGRAL 350
DEVRPISIET NVLPNAHGSC LFTRGQTQAL VVATLGTDGD AQMYDILTEK 400
TALIEKFMFN YNFPGFSVGE ASPLKAPGRR ELGHGNLAKR ALAPSIDINS 450
PYTIRLVSEI LESNGSSSMA SVCGGALALR AAGVDTQKLV AGVAMGLIFE 500
GDKHAVLTDI MGLEDHDGDM DFKVAGSSDG ITALQMDIKL GGISLEVLKE 550
ALYQAKRGRE HILNLMHQAD SKIEVNEDVL PKLELFSVDP SKIVDIIGQA 600
GKTIKEIIER FEVSIDLDRE KGEVKIAGGA KKNVDAAKDY IISITSKENS 650
RGFGKKPHGH DRRDKDRQKP TFNIGDEFDG VVKSVVDFGA FIELKDGVDG 700
LLHISKIKTP LNVGDRLKVC VSEQKGNKIS LSLVE 735
Length:735
Mass (Da):80,567
Last modified:September 11, 2007 - v1
Checksum:i9B6E933740BAC0AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAU00019.1.
RefSeqiWP_011992002.1. NC_009715.1.
YP_001407821.1. NC_009715.1.

Genome annotation databases

EnsemblBacteriaiEAU00019; EAU00019; CCV52592_0953.
GeneIDi5407861.
KEGGiccv:CCV52592_0953.
PATRICi20031464. VBICamCur47627_0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000767 Genomic DNA. Translation: EAU00019.1 .
RefSeqi WP_011992002.1. NC_009715.1.
YP_001407821.1. NC_009715.1.

3D structure databases

ProteinModelPortali A7GX79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360105.CCV52592_0953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAU00019 ; EAU00019 ; CCV52592_0953 .
GeneIDi 5407861.
KEGGi ccv:CCV52592_0953.
PATRICi 20031464. VBICamCur47627_0551.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CCUR360105:GJ9P-562-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Campylobacter curvus 525.92 isolated from human feces."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 525.92.

Entry informationi

Entry nameiPNP_CAMC5
AccessioniPrimary (citable) accession number: A7GX79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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