A7GWX9 (HIS4_CAMC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	Ccur92_04170
ORF Names:	CCV52592_1199

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter curvus

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01014.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_1000063197
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	127	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GWX9 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 076D189C31CB525D	FASTA	236	25,414
	10 20 30 40 50 60 MEIFPAIDLK EGKAVRLSKG DMRSAKIYSH APQELAKIFE GYGARWLHVV DLDGAFAGET 70 80 90 100 110 120 VNFDAVEKII KSTNLKVQIG GGIRDEARIK RYLDIGASRV ILGSVALNEP NFVREMAKIY 130 140 150 160 170 180 PVVVGIDAKE GFVATQGWAE VSQMRASELA AKFATAGVKA IICTDIAKDG MLGGVNLDFT 190 200 210 220 230 LEIARASGVD TIASGGVKDM SDIMRLKDSG EVAGVIVGKA YYEGKIDLKE AFRKVL

References

[1]

"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 525.92.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000767 Genomic DNA. Translation: EAU00996.1.
RefSeq	YP_001407721.1. NC_009715.1.
3D structure databases
ProteinModelPortal	A7GWX9.
ModBase	Search...
Protein-protein interaction databases
STRING	360105.CCV52592_1199.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EAU00996; EAU00996; CCV52592_1199.
GeneID	5407760.
KEGG	ccv:CCV52592_1199.
PATRIC	20031250. VBICamCur47627_0445.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0106.
HOGENOM	HOG000224614.
KO	K01814.
OMA	DGHCVRL.
ProtClustDB	PRK00748.
Enzyme and pathway databases
BioCyc	CCUR360105:GJ9P-456-MONOMER.
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR006063. HisA. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMs	TIGR00007. TIGR00007. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_CAMC5

Accession

Primary (citable) accession number: A7GWX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	May 29, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program