Reviewed, UniProtKB/Swiss-Prot A7GVZ7 (PROA_CAMC5)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	Ccur92_00850
ORF Names:	CCV52592_0754

Organism

Campylobacter curvus (strain 525.92) [Complete proteome] [HAMAP]

Taxonomic identifier

360105 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_1000060838

Sequences

	Sequence		Length	Mass (Da)
	A7GVZ7-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 9D68299F6CB79BA2	FASTA	442	47,155
	10 20 30 40 50 60 MSEILNIAKA AKASCEQLLN LSAQAKSQIL NAVADELVRQ KEAIKAANLL DLKAGENAGL 70 80 90 100 110 120 SAALLDRLEL TDARIEAMAN GVREVAKFDE VVGEVLGGWR HPNGMQITKI RVPLGVLGII 130 140 150 160 170 180 YESRPNVSID AAALALKSGN AVILRGSAAA ISSNKFLVNL FNETGAKFGL PKGAVALVES 190 200 210 220 230 240 TDKEAVGEMI KMHEFIDVLI PRGGKNLKDF IIQNATIPVI ETGAGVCHIF VDESADVREA 250 260 270 280 290 300 VEIIKNAKTQ RPSTCNSVEC VLLHERVAVK VLTSLARELD GVQLRVHEDL WAKFGENLGE 310 320 330 340 350 360 ISGDLDANLS GLKAEVKIGE SSNGAQLVKA DESDFGTEFL SLVLAVKCVS GVAEAVSYIN 370 380 390 400 410 420 SHSTHHSDAI LSRDYANIER FLNAVDSAVV YANASTRFSD GGEFGFGGEI GISTQKLHAR 430 440 GPMGVRELTT SKYVVRGDGQ IR

References

[1]	"Genome sequence of Campylobacter curvus 525.92 isolated from human feces." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Lastovica A.J., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000767 Genomic DNA. Translation: EAT99669.1.
RefSeq	YP_001407389.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5406596.
GenomeReviews	Gene locus Ccur92_00850 in contig CP000767_GR.
KEGG	ccv:CCV52592_0754.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7GVZ7. QYPAACN.
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_CAMC5

Accession

Primary (citable) accession number: A7GVZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)