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Protein

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG

Gene

mnmG

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei181 – 1811FADUniRule annotation
Binding sitei370 – 3701FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 196FADUniRule annotation
Nucleotide bindingi273 – 28715NADUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-4160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGUniRule annotation
Alternative name(s):
Glucose-inhibited division protein AUniRule annotation
Gene namesi
Name:mnmGUniRule annotation
Synonyms:gidAUniRule annotation
Ordered Locus Names:Bcer98_4023
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmGPRO_1000076307Add
BLAST

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_4023.

Structurei

3D structure databases

ProteinModelPortaliA7GVP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiEOG6W9X6J.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GVP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYNAGSYDV IVIGAGHAGC EAGLAAARMG SKTLMLTINL DMVAFMPCNP
60 70 80 90 100
SVGGPAKGIV VREIDALGGE MGRNIDKTHI QMRMLNTGKG PAVRALRAQA
110 120 130 140 150
DKFLYQHELK KTIEETPNLT LRQGMVERLI VEDGVCKGVI TQSGAEYTAK
160 170 180 190 200
TVVITTGTFL RGEIIMGDLK YSSGPNNQQP SITLSEHLEE LGFELVRFKT
210 220 230 240 250
GTPPRVNSNT IDYSKTEIQP GDDQPRAFSF ETTKFILDQI PCWLTYTSEE
260 270 280 290 300
THRLIDKNLH RSAMYSGMIK GTGPRYCPSI EDKVVRFNDK PRHQIFLEPE
310 320 330 340 350
GRNTQEVYVQ GLSTSLPEDV QREMLKTIPG LENVEMMRTG YAIEYDAIVP
360 370 380 390 400
TQLWPTLETK KIKNLYTAGQ INGTSGYEEA AGQGIMAGIN AACRSLGKKE
410 420 430 440 450
VILGRSDAYI GVLIDDLVTK GTNEPYRLLT SRAEYRLLLR HDNADLRLTE
460 470 480 490 500
IGHEIGLIPE ERYERYSQKK EQIEQEKARL EGIIIKPRPE VQELIRSVGG
510 520 530 540 550
SELKDGIRAS DLLRRPEMTY EHIRLLAPSE LEINDEVAEQ VEIQIKYEGY
560 570 580 590 600
IEKSLQQVER MKKMESKKIP VDIDYDAISG IASEARQKLK EVRPLSVGQA
610 620
SRISGVNPAD ISILLVYIEQ GKIARVSNQ
Length:629
Mass (Da):70,177
Last modified:September 11, 2007 - v1
Checksum:iE1F0EB12C68DC5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS24204.1.
RefSeqiWP_012096468.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS24204; ABS24204; Bcer98_4023.
KEGGibcy:Bcer98_4023.
PATRICi18936795. VBIBacCyt128034_4208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS24204.1.
RefSeqiWP_012096468.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GVP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_4023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS24204; ABS24204; Bcer98_4023.
KEGGibcy:Bcer98_4023.
PATRICi18936795. VBIBacCyt128034_4208.

Phylogenomic databases

eggNOGiENOG4107RE5. Bacteria.
COG0445. LUCA.
HOGENOMiHOG000201060.
KOiK03495.
OMAiFRPGYAI.
OrthoDBiEOG6W9X6J.

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-4160-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00129. MnmG_GidA.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR026904. GidA-assoc_3.
IPR004416. MnmG.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
PF13932. GIDA_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR00136. gidA. 1 hit.
PROSITEiPS01280. GIDA_1. 1 hit.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22905 / CIP 110041 / 391-98 / NVH 391-98.

Entry informationi

Entry nameiMNMG_BACCN
AccessioniPrimary (citable) accession number: A7GVP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.