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A7GVJ5 (A7GVJ5_BACCN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP reductase HAMAP MF_01511
EC=1.7.1.7 HAMAP MF_01511
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_01511
Gene names
Name:guaC HAMAP MF_01511
Ordered Locus Names:Bcer98_3971
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP] EMBL ABS24153.1
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 SAAS SAAS005994

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 SAAS SAAS005994

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. HAMAP MF_01511

Ontologies

Keywords
   LigandNADP HAMAP MF_01511 SAAS SAAS005994
   Molecular functionOxidoreductase HAMAP MF_01511 SAAS SAAS005994
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding204 – 22724NADP By similarity HAMAP MF_01511

Sites

Active site1751Thioimidate intermediate By similarity HAMAP MF_01511

Sequences

Sequence LengthMass (Da)Tools
A7GVJ5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B504269A3E950236

FASTA32736,190
        10         20         30         40         50         60 
MENVFDYEDI QLIPAKCIVN SRSECDTSIT LGKHKFKLPV VPANMQTIID EKIATYLAEN 

        70         80         90        100        110        120 
NYFYIMHRFQ PETRMAFVRD MQSRGLIASI SVGVKEEEYE FIKQLAAEQL SPEYITIDIA 

       130        140        150        160        170        180 
HGHSNAVIQM IQHIKKYLPE SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 

       190        200        210        220        230        240 
TGFGTGGWQL AALRWCAKAA SKPVIADGGI RTHGDIAKSI RFGATMVMIG SLFAGHEESP 

       250        260        270        280        290        300 
GETIEKDGKL YKEYFGSASE FQKGERKNVE GKKMFVEHKG SLKDTLIEME QDLQSSISYA 

       310        320 
GGTKLESIRT VDYVVVKNSI FNGDKVY

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000764 Genomic DNA. Translation: ABS24153.1.
RefSeqYP_001377148.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GVJ5.
SMRA7GVJ5. Positions 1-321.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GVJ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000039632; EBBACP00000038683; EBBACG00000039623.
GeneID5345526.
GenomeReviewsGene locus Bcer98_3971 in contig CP000764_GR.
KEGGbcy:Bcer98_3971.
PATRIC18936683. VBIBacCyt128034_4156.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
GeneTreeEBGT00050000000995.
HOGENOMHBG298985.
OMAPDYITID.
ProtClustDBPRK05458.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7GVJ5_BACCN
AccessionPrimary (citable) accession number: A7GVJ5
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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