A7GUA6 (G6PI_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Bcer98_3509

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000081230
Sites
	Active site	291	1	Proton donor By similarity
	Active site	312	1	By similarity
	Active site	426	1	By similarity
Amino acid modifications
	Modified residue	39	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GUA6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 3701DCC955D143AE	FASTA	450	50,345
	10 20 30 40 50 60 MSTHVTFDYS KALSFISEHE LTYLRDAVKV SHHAIHEKTG AGNDFLGWVD LPLAYDKEEF 70 80 90 100 110 120 IRIQKCAEKI KNDSDILLVI GIGGSYLGAR AAIEMLNHSF YNMLSKEQRK TPQVLFVGQN 130 140 150 160 170 180 ISSTYMKDLM DVLEGKDFSI NVISKSGTTT EPAIAFRLFR KLLEDKYGKE EARKRIYATT 190 200 210 220 230 240 DKARGALKTL ADEEGYETFV IPDDVGGRFS VLTPVGLLPI AVSGLSIEEM MQGAAAGCND 250 260 270 280 290 300 FAKSELEENP AYQYAVVRNA LYNKGKTIEM LVNYEPALQY FAEWWKQLFG ESEGKDQKGI 310 320 330 340 350 360 FPSSANFSTD LHSLGQYIQE GRRDLFETVL KVGKPTHELT IELDESDLDG LNYLAGKTVD 370 380 390 400 410 420 FVNTKAYEGT LLAHSDGGVP NLIVNIPELN EYTFGYLVYF FEKACAMSGY LLGVNPFDQP 430 440 450 GVEAYKKNMF ALLGKPGFEE LKAELEERLK

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS23714.1.
RefSeq	YP_001376709.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GUA6.
SMR	A7GUA6. Positions 5-449.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GUA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000036459; EBBACP00000035510; EBBACG00000036450.
GeneID	5347131.
GenomeReviews	Gene locus Bcer98_3509 in contig CP000764_GR.
KEGG	bcy:Bcer98_3509.
PATRIC	18935720. VBIBacCyt128034_3676.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
GeneTree	EBGT00050000001561.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_3509-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACCN

Accession

Primary (citable) accession number: A7GUA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program