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A7GU19

- SYL_BACCN

UniProt

A7GU19 - SYL_BACCN

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Protein
Leucine--tRNA ligase
Gene
leuS, Bcer98_3415
Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-3525-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Bcer98_3415
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Leucine--tRNA ligaseUniRule annotation
PRO_1000074824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_3415.

Structurei

3D structure databases

ProteinModelPortaliA7GU19.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GU19-1 [UniParc]FASTAAdd to Basket

« Hide

MSFNHQEIEK KWQAYWEENK TFRTPDETDK PKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNSPAEFT 100
EKNINTFRNQ IKSLGFSYDW DREVNTTDPN YYKWTQWIFL KLFEKGLAYV 150
DEIPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW MLKITAYADR 200
LLEDLDELDW PESLKDMQRN WIGRSEGAEV HFNIDGTDKK FTIFTTRPDT 250
LFGATYCVLA PEHALVAEIT TEDQKGAVEA YIDVVKSKSD LERTELAKEK 300
TGVFTGAYAI NPVNGEKLPI WIADYVLASY GTGAVMAVPA HDERDYEFAK 350
TFDLPMKEVV KGGDITKEAY TADGEHIDSA FLNGLNKEEA IAKMIEWLEV 400
TGAGNQKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTMTAV KEEELPLVLP 450
KTDNIRPSGT GESPLANIDE WVNVVDPETG KKGRRETNTM PQWAGSCWYY 500
LRYIDPNNNE ALVDPEKAKQ WLPVDIYIGG AEHAVLHLLY ARFWHKVLYD 550
IGVVPTKEPF QQLFNQGMIL GENNEKMSKS KGNVVNPDDI VASHGADTLR 600
LYEMFMGPLD ASIAWSENGL DGARRFLDRV WRLFVQENGE LSEKITDAPN 650
KELEKAYHQT VKKVTEDYEE LHFNTAISQM MMFINDAYKA ETLPKEYVEG 700
FVKLLAPVAP HIAEELWSKL GYNETITYAS WPTFDESKLV EDEVEIVVQV 750
MGKVRAKLKM KKDASKEEME QLALEEVKEQ IEGKTVRKVI VVPGKLVNIV 800
AN 802
Length:802
Mass (Da):91,593
Last modified:September 11, 2007 - v1
Checksum:iBE0656D9D4109E08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23627.1.
RefSeqiYP_001376622.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS23627; ABS23627; Bcer98_3415.
GeneIDi5346829.
KEGGibcy:Bcer98_3415.
PATRICi18935480. VBIBacCyt128034_3581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23627.1 .
RefSeqi YP_001376622.1. NC_009674.1.

3D structure databases

ProteinModelPortali A7GU19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315749.Bcer98_3415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS23627 ; ABS23627 ; Bcer98_3415 .
GeneIDi 5346829.
KEGGi bcy:Bcer98_3415.
PATRICi 18935480. VBIBacCyt128034_3581.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BCYT315749:GH2A-3525-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiSYL_BACCN
AccessioniPrimary (citable) accession number: A7GU19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi