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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Bcer98_3415
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000748241 – 802Leucine--tRNA ligaseAdd BLAST802

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_3415

Structurei

3D structure databases

ProteinModelPortaliA7GU19
SMRiA7GU19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7GU19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNHQEIEK KWQAYWEENK TFRTPDETDK PKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNSPAEFT
110 120 130 140 150
EKNINTFRNQ IKSLGFSYDW DREVNTTDPN YYKWTQWIFL KLFEKGLAYV
160 170 180 190 200
DEIPVNWCPA LGTVLANEEV IDGKSERGGH PVERRPMKQW MLKITAYADR
210 220 230 240 250
LLEDLDELDW PESLKDMQRN WIGRSEGAEV HFNIDGTDKK FTIFTTRPDT
260 270 280 290 300
LFGATYCVLA PEHALVAEIT TEDQKGAVEA YIDVVKSKSD LERTELAKEK
310 320 330 340 350
TGVFTGAYAI NPVNGEKLPI WIADYVLASY GTGAVMAVPA HDERDYEFAK
360 370 380 390 400
TFDLPMKEVV KGGDITKEAY TADGEHIDSA FLNGLNKEEA IAKMIEWLEV
410 420 430 440 450
TGAGNQKVTY RLRDWLFSRQ RYWGEPIPII HWEDGTMTAV KEEELPLVLP
460 470 480 490 500
KTDNIRPSGT GESPLANIDE WVNVVDPETG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPNNNE ALVDPEKAKQ WLPVDIYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
IGVVPTKEPF QQLFNQGMIL GENNEKMSKS KGNVVNPDDI VASHGADTLR
610 620 630 640 650
LYEMFMGPLD ASIAWSENGL DGARRFLDRV WRLFVQENGE LSEKITDAPN
660 670 680 690 700
KELEKAYHQT VKKVTEDYEE LHFNTAISQM MMFINDAYKA ETLPKEYVEG
710 720 730 740 750
FVKLLAPVAP HIAEELWSKL GYNETITYAS WPTFDESKLV EDEVEIVVQV
760 770 780 790 800
MGKVRAKLKM KKDASKEEME QLALEEVKEQ IEGKTVRKVI VVPGKLVNIV

AN
Length:802
Mass (Da):91,593
Last modified:September 11, 2007 - v1
Checksum:iBE0656D9D4109E08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS23627.1
RefSeqiWP_012095876.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS23627; ABS23627; Bcer98_3415
GeneIDi33898654
KEGGibcy:Bcer98_3415

Similar proteinsi

Entry informationi

Entry nameiSYL_BACCN
AccessioniPrimary (citable) accession number: A7GU19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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