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A7GTW9

- TRMB_BACCN

UniProt

A7GTW9 - TRMB_BACCN

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Bcer98_3362
Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosyl-L-methionine By similarity
Binding sitei69 – 691S-adenosyl-L-methionine By similarity
Binding sitei96 – 961S-adenosyl-L-methionine By similarity
Active sitei118 – 1181 By similarity
Binding sitei118 – 1181S-adenosyl-L-methionine By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei154 – 1541Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-3472-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Bcer98_3362
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000084436Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_3362.

Structurei

3D structure databases

ProteinModelPortaliA7GTW9.
SMRiA7GTW9. Positions 11-213.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1944Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7GTW9-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRHKPYAM DRIKEYSQFV IGNPEEHRGN WKELFGNDHP IHIEVGTGRG    50
RFVYEMAKAN PDINYIGIEK FTSVIVDALD KLIEKELPNL KLINKDAEDL 100
TVFFTKGEID RVYLNFSDPW PKKRHAKRRL TYKTFLRNYE EVLVKDGEIH 150
FKTDNQALFE YSLMSMAEYG MVFTFLSLDL HNSDFEGNIM TEYEEKFSSK 200
GHRIYRVEAK YRTEPVQ 217
Length:217
Mass (Da):25,730
Last modified:September 11, 2007 - v1
Checksum:i684E59B47C5497CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23577.1.
RefSeqiYP_001376572.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS23577; ABS23577; Bcer98_3362.
GeneIDi5346616.
KEGGibcy:Bcer98_3362.
PATRICi18935370. VBIBacCyt128034_3526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23577.1 .
RefSeqi YP_001376572.1. NC_009674.1.

3D structure databases

ProteinModelPortali A7GTW9.
SMRi A7GTW9. Positions 11-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315749.Bcer98_3362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS23577 ; ABS23577 ; Bcer98_3362 .
GeneIDi 5346616.
KEGGi bcy:Bcer98_3362.
PATRICi 18935370. VBIBacCyt128034_3526.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BCYT315749:GH2A-3472-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiTRMB_BACCN
AccessioniPrimary (citable) accession number: A7GTW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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