Skip Header

Contribute Send feedback
Read comments (?) or add your own

A7GTR4 (ARLY_BACCN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Bcer98_3305
OrganismBacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]
Taxonomic identifier315749 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Argininosuccinate lyase HAMAP MF_00006
PRO_0000321430

Sequences

Sequence LengthMass (Da)Tools
A7GTR4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 87963B0198303832

FASTA46252,245
        10         20         30         40         50         60 
MSKLWGGRFT EEAEAWVEEF GASISFDKQL VKQDIEGSIA HVMMLAKQGI VTNDEAEKIK 

        70         80         90        100        110        120 
EGLQYLLEEA KENKLHFSVE AEDVHLNIEK MLIEQIGEVG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LKEKVQDIIN AIKQLQKVLV DQAEENIETI MPGYTHLQRA QPISFAHHIL AYFWMLERDV 

       190        200        210        220        230        240 
NRYEDSLKRI NVSPLGAGAL AGTTFPIDRA YSAKLLDFEG IYENSLDAVS DRDFILEFLS 

       250        260        270        280        290        300 
NSSMLMMHIS RFCEELILWS SQEFQFIEMS DRYATGSSIM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GNLFSLLTVM KGLPLAYNKD LQEDKEGMFD TVKTVEGCLH IMAGMLETMT VNKENMGQAV 

       370        380        390        400        410        420 
TQDFSNATEV ADYLANKGLP FRQAHEIVGK LVLHCTKKGI YLLDVPLETY KEMSPLFEED 

       430        440        450        460 
LYEVLSPYAA VKRRNSAGGT GFVQIEQALE KAKILVGEVT RN

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NVH 391-98.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000764 Genomic DNA. Translation: ABS23522.1.
RefSeqYP_001376517.1. NC_009674.1.

3D structure databases

ProteinModelPortalA7GTR4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7GTR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000039814; EBBACP00000038865; EBBACG00000039805.
GeneID5343910.
GenomeReviewsGene locus Bcer98_3305 in contig CP000764_GR.
KEGGbcy:Bcer98_3305.
PATRIC18935256. VBIBacCyt128034_3469.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00070000031828.
HOGENOMHBG539632.
OMAEDIHTVI.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBCER315749:BCER98_3305-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_BACCN
AccessionPrimary (citable) accession number: A7GTR4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents