Reviewed, UniProtKB/Swiss-Prot A7GT28 (AROE_BACCN)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Bcer98_3060

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Shikimate dehydrogenase		PRO_1000078112
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A7GT28-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 58E51B252CA5A000	FASTA	277	30,238
	10 20 30 40 50 60 MKQLYGVIGN PIGHSLSPLM HNDAFEHLGI DAHYHAFLVE EEMLGEAVKG LKALGVSGIN 70 80 90 100 110 120 VTTPHKVAIM KYLDEIDPLA KQIGAVNTVV HRNGKLVGYN TDGIGYVRSL QAISKEPLRH 130 140 150 160 170 180 KRMLLLGAGG ACRAIYCSLV AAGVKEIDIA NRTVETAKQL IASSKERVVS KALSLEKATE 190 200 210 220 230 240 AQENYDVLIQ TTTIGMHPHV QHTPMQIGSL KQGAIVSDII YNPFETKFLH DAKLSGAIVQ 250 260 270 NGIDMFVYQG ALAFEMWTGM MPDINRMKQL VIRKLGG

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000764 Genomic DNA. Translation: ABS23286.1.
RefSeq	YP_001376281.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5346628.
GenomeReviews	Gene locus Bcer98_3060 in contig CP000764_GR.
KEGG	bcy:Bcer98_3060.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BACCN

Accession

Primary (citable) accession number: A7GT28

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	November 25, 2008
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)