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A7GSN6

- GCSPB_BACCN

UniProt

A7GSN6 - GCSPB_BACCN

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Bcer98_2913
Organism
Bacillus cereus subsp. cytotoxis (strain NVH 391-98)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBCYT315749:GH2A-3021-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Bcer98_2913
OrganismiBacillus cereus subsp. cytotoxis (strain NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002300: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000083227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi315749.Bcer98_2913.

Structurei

3D structure databases

ProteinModelPortaliA7GSN6.
SMRiA7GSN6. Positions 7-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GSN6-1 [UniParc]FASTAAdd to Basket

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MKNQDQALIF EMSKEGRVGY SLPQLDVEEV KLEDVFESNY IRAEDAELPE    50
VSELDIMRHY TALSNRNHGV DSGFYPLGSC TMKYNPKINE NVARFPGFAN 100
IHPLQDEKTV QGAMELMYDL QEHLVEITGM DAVTLQPAAG AHGEWTGLML 150
IRAYHEANGD HNRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDL 200
EDLKRVVNEE TAALMLTNPN TLGLFEENIL EMAEIVHNAG GKLYYDGANL 250
NAVLSQARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKEDLIPFLP 300
KPILEKTENG YHFNYDRPQA IGRVKPFYGN FGINVRAYTY IRSMGPDGLR 350
AVTENAVLNA NYMMRRLAPY YDLPFDRHCK HEFVLSGRCQ KKLGVRTLDI 400
AKRLLDFGYH PPTIYFPLNV EECIMIEPTE TESKETLDGF IDKMIQIAKE 450
AKENPEIVQE APHTTVITRL DETMAARKPI LRYQKPTPVQ V 491
Length:491
Mass (Da):54,867
Last modified:September 11, 2007 - v1
Checksum:i6C31F335795C2718
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23144.1.
RefSeqiYP_001376139.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS23144; ABS23144; Bcer98_2913.
GeneIDi5347262.
KEGGibcy:Bcer98_2913.
PATRICi18934440. VBIBacCyt128034_3064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000764 Genomic DNA. Translation: ABS23144.1 .
RefSeqi YP_001376139.1. NC_009674.1.

3D structure databases

ProteinModelPortali A7GSN6.
SMRi A7GSN6. Positions 7-485.
ModBasei Search...

Protein-protein interaction databases

STRINGi 315749.Bcer98_2913.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS23144 ; ABS23144 ; Bcer98_2913 .
GeneIDi 5347262.
KEGGi bcy:Bcer98_2913.
PATRICi 18934440. VBIBacCyt128034_3064.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BCYT315749:GH2A-3021-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NVH 391-98.

Entry informationi

Entry nameiGCSPB_BACCN
AccessioniPrimary (citable) accession number: A7GSN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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