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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Bcer98_2913
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832271 – 491Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi315749.Bcer98_2913

Structurei

3D structure databases

ProteinModelPortaliA7GSN6
SMRiA7GSN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RGW Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A7GSN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQDQALIF EMSKEGRVGY SLPQLDVEEV KLEDVFESNY IRAEDAELPE
60 70 80 90 100
VSELDIMRHY TALSNRNHGV DSGFYPLGSC TMKYNPKINE NVARFPGFAN
110 120 130 140 150
IHPLQDEKTV QGAMELMYDL QEHLVEITGM DAVTLQPAAG AHGEWTGLML
160 170 180 190 200
IRAYHEANGD HNRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDL
210 220 230 240 250
EDLKRVVNEE TAALMLTNPN TLGLFEENIL EMAEIVHNAG GKLYYDGANL
260 270 280 290 300
NAVLSQARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKEDLIPFLP
310 320 330 340 350
KPILEKTENG YHFNYDRPQA IGRVKPFYGN FGINVRAYTY IRSMGPDGLR
360 370 380 390 400
AVTENAVLNA NYMMRRLAPY YDLPFDRHCK HEFVLSGRCQ KKLGVRTLDI
410 420 430 440 450
AKRLLDFGYH PPTIYFPLNV EECIMIEPTE TESKETLDGF IDKMIQIAKE
460 470 480 490
AKENPEIVQE APHTTVITRL DETMAARKPI LRYQKPTPVQ V
Length:491
Mass (Da):54,867
Last modified:September 11, 2007 - v1
Checksum:i6C31F335795C2718
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS23144.1
RefSeqiWP_012095372.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS23144; ABS23144; Bcer98_2913
GeneIDi33898165
KEGGibcy:Bcer98_2913

Similar proteinsi

Entry informationi

Entry nameiGCSPB_BACCN
AccessioniPrimary (citable) accession number: A7GSN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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