A7GSF2 (ARGB_BACCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Bcer98_2827

Organism

Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [Complete proteome] [HAMAP]

Taxonomic identifier

315749 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000075301
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	212	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7GSF2 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: AACD4BCEBE257DB5	FASTA	256	28,050
	10 20 30 40 50 60 MNECIVIKCG GSMLERLDST FFHCIEKLKR KYRIVIVHGG GPDIDKILKK LQIPIEKKHG 70 80 90 100 110 120 LRVTSQEVME VVQMVLCGST NKNLVQNFQR YGLPAIGISG CDGKLLQAKP LNKKIGYVGE 130 140 150 160 170 180 VSKVESSLLE GVLNLNYIPI IAPIGIGEEQ VYNINADIAA AGIAAALRVK ELIFITDVDG 190 200 210 220 230 240 LLYEGKLVKK TDEIEILDMI EKEIITGGMI PKVQAALVAL RMGIQSVSIV NGTKNFIGLT 250 GEWIGTTVTR GRLQYE

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NVH 391-98.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000764 Genomic DNA. Translation: ABS23060.1.
RefSeq	YP_001376055.1. NC_009674.1.
3D structure databases
ProteinModelPortal	A7GSF2.
ModBase	Search...
Protein-protein interaction databases
STRING	A7GSF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000039012; EBBACP00000038063; EBBACG00000039003.
GeneID	5343684.
GenomeReviews	Gene locus Bcer98_2827 in contig CP000764_GR.
KEGG	bcy:Bcer98_2827.
PATRIC	18934268. VBIBacCyt128034_2978.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
GeneTree	EBGT00050000001971.
HOGENOM	HBG497643.
OMA	CNINVEK.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	BCER315749:BCER98_2827-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACCN

Accession

Primary (citable) accession number: A7GSF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program