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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processBiotin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Bcer98_2814
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124791 – 285Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST285

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_2814.

Structurei

3D structure databases

ProteinModelPortaliA7GSD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiATYQVVY.
OrthoDBiPOG091H05JY.

Family and domain databases

HAMAPiMF_00835. BioC. 1 hit.
InterProiView protein in InterPro
IPR011814. BioC.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF13847. Methyltransf_31. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GSD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKTLLQKR FNRAAVSYDQ YANVQKKMAR HLLSQLEKRY SKAAAIRILE
60 70 80 90 100
LGCGTGYITE KLVHLFPNAQ ITAIDFAESM IAVAKQRRHV DEVTFRCEDI
110 120 130 140 150
EKLILDDFYD VIISNATFQW LNDLQVSLVK LYKHLAGEGI LLFSTFGNRT
160 170 180 190 200
FQELHRAFER AKEEKNIKSH VSIGQRLFTK AQLQNICSIK KGNVHVSETC
210 220 230 240 250
YIEKFTHVRD FFKSIRKVGA TNSNEDTYCQ SPSLFRAMLR IYERDFTKEG
260 270 280
EIIATYHALF AHIEKEGKRR NETNTNKSRL EENCV
Length:285
Mass (Da):33,083
Last modified:September 11, 2007 - v1
Checksum:iD513F9D62C39A9F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS23047.1.
RefSeqiWP_012095273.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS23047; ABS23047; Bcer98_2814.
GeneIDi33898070.
KEGGibcy:Bcer98_2814.

Similar proteinsi

Entry informationi

Entry nameiBIOC_BACCN
AccessioniPrimary (citable) accession number: A7GSD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 11, 2007
Last modified: October 25, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families