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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:Bcer98_2814
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004124791 – 285Malonyl-[acyl-carrier protein] O-methyltransferaseAdd BLAST285

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_2814.

Structurei

3D structure databases

ProteinModelPortaliA7GSD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiSADYWLF.
OrthoDBiPOG091H05JY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.

Sequencei

Sequence statusi: Complete.

A7GSD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKTLLQKR FNRAAVSYDQ YANVQKKMAR HLLSQLEKRY SKAAAIRILE
60 70 80 90 100
LGCGTGYITE KLVHLFPNAQ ITAIDFAESM IAVAKQRRHV DEVTFRCEDI
110 120 130 140 150
EKLILDDFYD VIISNATFQW LNDLQVSLVK LYKHLAGEGI LLFSTFGNRT
160 170 180 190 200
FQELHRAFER AKEEKNIKSH VSIGQRLFTK AQLQNICSIK KGNVHVSETC
210 220 230 240 250
YIEKFTHVRD FFKSIRKVGA TNSNEDTYCQ SPSLFRAMLR IYERDFTKEG
260 270 280
EIIATYHALF AHIEKEGKRR NETNTNKSRL EENCV
Length:285
Mass (Da):33,083
Last modified:September 11, 2007 - v1
Checksum:iD513F9D62C39A9F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS23047.1.
RefSeqiWP_012095273.1. NC_009674.1.

Genome annotation databases

EnsemblBacteriaiABS23047; ABS23047; Bcer98_2814.
KEGGibcy:Bcer98_2814.
PATRICi18934242. VBIBacCyt128034_2965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA. Translation: ABS23047.1.
RefSeqiWP_012095273.1. NC_009674.1.

3D structure databases

ProteinModelPortaliA7GSD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_2814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS23047; ABS23047; Bcer98_2814.
KEGGibcy:Bcer98_2814.
PATRICi18934242. VBIBacCyt128034_2965.

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiSADYWLF.
OrthoDBiPOG091H05JY.

Enzyme and pathway databases

UniPathwayiUPA00078.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIOC_BACCN
AccessioniPrimary (citable) accession number: A7GSD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.